A causal link between chronic inflammation and carcinogenesis is explored by reviewing
illustrative examples of specific cancers and causal agents and mechanisms. The causal …

Prostate cancer remains a significant health concern for men throughout the world. Recently,
there has developed an expanding multidisciplinary body of literature suggesting a link …

Prostate cancer is among the most common malignancies. It is estimated that 1 in 6 men in
the United States will be diagnosed with this disease. Despite the high prevalence and …

Prostate cancer is an increasing threat throughout the world. As a result of a demographic
shift in population, the number of men at risk for developing prostate cancer is growing …

Purpose: We investigated an association between chronic prostatic inflammation and
prostate carcinogenesis. Materials and Methods: Initial prostate needle biopsies from 177 …

Bostwick DG & Cheng L (2012) Histopathology 60, 4–27 Precursors of prostate cancer High‐
grade prostatic intraepithelial neoplasia (PIN) is the only accepted precursor of prostatic …

PURPOSE The ability of an endocrine disruptor exposure during gonadal sex determination
to promote a transgenerational prostate disease phenotype was investigated in the current …

Focal atrophy is extremely common in prostate specimens. Although there are distinct
histologic variants, the terminology is currently nonstandardized and no formal classification …

BACKGROUND Inflammation has been implicated as a potential etiological agent in human
prostate cancer (PCa). Proliferative inflammatory atrophy (PIA) in prostate consists of areas …

Background: A challenge in prostate cancer (PCa) management is identifying potentially
lethal disease at diagnosis. Inflammation, focal prostatic atrophy, and prostatic intraepithelial …