Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

STING is an innate immune cytosolic adaptor for DNA sensors that engage malaria parasite
(Plasmodium falciparum) or other pathogen DNA. As P. falciparum infects red blood cells …

The efficacious detection of pathogens and prompt induction of innate immune signaling
serve as a crucial component of immune defense against infectious pathogens. Over the …

The intracellular microbial nucleic acid sensors, TLR3 and STING, recognize pathogen
molecules and signal to activate the interferon pathway. The TIR-domain containing protein …

Innate immunity acts as the first line of defense against pathogen invasion. During
Toxoplasma gondii infection, multiple innate immune sensors are activated by invading …

Cytosolic DNA sensing is a fundamental mechanism by which organisms handle various
stresses, including infection and genotoxicity. The hematopoietic system is sensitive to …

Toxoplasma gondii is an important neurotropic pathogen that establishes latent infections in
humans that can cause toxoplasmosis in immunocompromised individuals. It replicates …

Mycobacterium bovis (M. bovis) is highly adapted to macrophages and has developed
multiple mechanisms to resist intracellular assaults. However, the host cells in turn deploy a …

Stimulator of interferon genes (STING, also known as MITA, ERIS, MPYS or TMEM173) has
been identified as a central component in the innate immune response to cytosolic DNA and …