In silico methods and tools for drug discovery

B Shaker, S Ahmad, J Lee, C Jung, D Na - Computers in biology and …, 2021 - Elsevier
In the past, conventional drug discovery strategies have been successfully employed to
develop new drugs, but the process from lead identification to clinical trials takes more than …

Developing natural products as potential anti-biofilm agents

L Lu, W Hu, Z Tian, D Yuan, G Yi, Y Zhou, Q Cheng… - Chinese medicine, 2019 - Springer
Biofilm is a natural form of bacterial growth ubiquitously in environmental niches. The biofilm
formation results in increased resistance to negative environmental influences including …

Plant natural products targeting bacterial virulence factors

LN Silva, KR Zimmer, AJ Macedo, DS Trentin - Chemical reviews, 2016 - ACS Publications
Decreased antimicrobial efficiency has become a global public health issue. The paucity of
new antibacterial drugs is evident, and the arsenal against infectious diseases needs to be …

The Formation of Biofilms by Pseudomonas aeruginosa: A Review of the Natural and Synthetic Compounds Interfering with Control Mechanisms

T Rasamiravaka, Q Labtani, P Duez… - BioMed research …, 2015 - Wiley Online Library
P. aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and
chronic infections. Beyond its natural resistance to many drugs, its ability to form biofilm, a …

Biofilm, pathogenesis and prevention—a journey to break the wall: a review

P Gupta, S Sarkar, B Das, S Bhattacharjee… - Archives of …, 2016 - Springer
Biofilms contain group (s) of microorganisms that are found to be associated with the biotic
and abiotic surfaces. Biofilms contain either homogenous or heterogeneous populations of …

Current and recent advanced strategies for combating biofilms

M Sadekuzzaman, S Yang… - … Reviews in Food …, 2015 - Wiley Online Library
Biofilms are matrix‐enclosed microbial aggregates that adhere to a biological or
nonbiological surface. Biofilm formation is a significant problem in the medical, food, and …

New perspectives on the use of phytochemicals as an emergent strategy to control bacterial infections including biofilms

A Borges, AC Abreu, C Dias, MJ Saavedra, F Borges… - Molecules, 2016 - mdpi.com
The majority of current infectious diseases are almost untreatable by conventional antibiotic
therapy given the advent of multidrug-resistant bacteria. The degree of severity and the …

[HTML][HTML] Screening strategies for quorum sensing inhibitors in combating bacterial infections

L Lu, M Li, G Yi, L Liao, Q Cheng, J Zhu… - Journal of …, 2022 - Elsevier
Interference with quorum sensing (QS) represents an antivirulence strategy with significant
promise for the treatment of bacterial infections and a new approach for restoring antibiotic …

[HTML][HTML] Quorum quenching mediated approaches for control of membrane biofouling

H Lade, D Paul, JH Kweon - International journal of biological …, 2014 - ncbi.nlm.nih.gov
Membrane biofouling is widely acknowledged as the most frequent adverse event in
wastewater treatment systems resulting in significant loss of treatment efficiency and …

Rutin inhibits mono and multi-species biofilm formation by foodborne drug resistant Escherichia coli and Staphylococcus aureus

NA Al-Shabib, FM Husain, I Ahmad, MS Khan… - Food control, 2017 - Elsevier
Considering the role of biofilm in food spoilage and the food industry, inhibition of biofilm
formation by natural agents is expected to be safe and could also enhance the efficacy of …