Energy metabolism in heart failure and remodelling
JS Ingwall - Cardiovascular research, 2009 - academic.oup.com
Myocytes of the failing heart undergo impressive metabolic remodelling. The time line for
changes in the pathways for ATP synthesis in compensated hypertrophy is: flux through the …
changes in the pathways for ATP synthesis in compensated hypertrophy is: flux through the …
Thin filament mutations: developing an integrative approach to a complex disorder
JC Tardiff - Circulation research, 2011 - Am Heart Assoc
Sixteen years ago, mutations in cardiac troponin (Tn) T and α-tropomyosin were linked to
familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β …
familial hypertrophic cardiomyopathy, thus transforming the disorder from a disease of the β …
Whole genome sequencing improves outcomes of genetic testing in patients with hypertrophic cardiomyopathy
Background: Whole genome sequencing (WGS) is a comprehensive genetic testing
approach that reports most types of nucleotide variants. Objectives: This study sought to …
approach that reports most types of nucleotide variants. Objectives: This study sought to …
Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics
Cardiac muscle relaxation is an essential step in the cardiac cycle. Even when the
contraction of the heart is normal and forceful, a relaxation phase that is too slow will limit …
contraction of the heart is normal and forceful, a relaxation phase that is too slow will limit …
Pathogenesis of hypertrophic cardiomyopathy is mutation rather than disease specific: a comparison of the cardiac troponin T E163R and R92Q mouse models
C Ferrantini, R Coppini, JM Pioner… - Journal of the …, 2017 - Am Heart Assoc
Background In cardiomyocytes from patients with hypertrophic cardiomyopathy, mechanical
dysfunction and arrhythmogenicity are caused by mutation‐driven changes in myofilament …
dysfunction and arrhythmogenicity are caused by mutation‐driven changes in myofilament …
Mechanisms of sympathoadrenal failure and hypoglycemia in diabetes
PE Cryer - The Journal of clinical investigation, 2006 - Am Soc Clin Investig
A reduced sympathoadrenal response, induced by recent antecedent hypoglycemia, is the
key feature of hypoglycemia-associated autonomic failure (HAAF) and, thus, the …
key feature of hypoglycemia-associated autonomic failure (HAAF) and, thus, the …
Differences in molecular phenotype in mouse and human hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is characterized by phenotypic heterogeneity. We
investigated the molecular basis of the cardiac phenotype in two mouse models at …
investigated the molecular basis of the cardiac phenotype in two mouse models at …
A model of calcium activation of the cardiac thin filament
The cardiac thin filament regulates actomyosin interactions through calcium-dependent
alterations in the dynamics of cardiac troponin and tropomyosin. Over the past several …
alterations in the dynamics of cardiac troponin and tropomyosin. Over the past several …
Atomic resolution probe for allostery in the regulatory thin filament
MR Williams, SJ Lehman, JC Tardiff… - Proceedings of the …, 2016 - National Acad Sciences
Calcium binding and dissociation within the cardiac thin filament (CTF) is a fundamental
regulator of normal contraction and relaxation. Although the disruption of this complex …
regulator of normal contraction and relaxation. Although the disruption of this complex …
Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility
Cardiac troponin (cTn) acts as a pivotal regulator of muscle contraction and relaxation and is
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …