Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …

Sarcopenia is a major component of the frailty syndrome, both being considered as strong
predictors of morbidity, disability, and death in older people. In this review, we explore the …

As we age, there is an age-related loss in skeletal muscle mass and strength, known as
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …

Skeletal muscle abnormalities are responsible for significant disability in the elderly.
Sarcopenia is the main alteration occurring during senescence and a key public health …

Abstract Changes in the neuromuscular system affecting the ageing motor unit manifest
structurally as a reduction in motor unit number secondary to motor neuron loss; fibre type …

Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Transmission of external stimuli to intracellular effector proteins via signalling …

Aging is associated with a progressive loss of muscle mass and strength and a decline in
neurophysiological functions. Age-related neuromuscular junction (NMJ) plays a key role in …

Frailty is a functional status that precedes disability and is characterized by decreased
functional reserve and increased vulnerability. In addition to disability, the frailty phenotype …

Age-related loss of skeletal muscle mass and contractile dysfunction, or sarcopenia, reduces
independence and quality of life in the elderly and leads to increased risk of comorbidities …

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motoneurons
and degradation of the neuromuscular junctions (NMJ). Consistent with the dying-back …