Oxidative stress response pathways in fungi

H Yaakoub, S Mina, A Calenda, JP Bouchara… - Cellular and Molecular …, 2022 - Springer
Fungal response to any stress is intricate, specific, and multilayered, though it employs only
a few evolutionarily conserved regulators. This comes with the assumption that one …

Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities

EM Huber - ChemBioChem, 2022 - Wiley Online Library
Epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites that share a 2, 5‐
diketopiperazine scaffold built from two amino acids and bridged by a sulfide moiety …

Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection

P Alves de Castro, C Figueiredo Pinzan… - Nature …, 2024 - nature.com
Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …

Enhancing gliotoxins production in deep-sea derived fungus Dichotomocyes cejpii by engineering the biosynthetic pathway

W Ye, T Liu, Y Liu, M Li, S Wang, S Li, W Zhang - Bioresource Technology, 2023 - Elsevier
Gliotoxin can be developed as potent biopesticide. In this study, the positive transcriptional
factor gliZ, glutathione-S transferase encoding gene gliG and gliN were firstly deleted by …

Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp.

F Palmieri, A Koutsokera, E Bernasconi, P Junier… - Frontiers in …, 2022 - frontiersin.org
Fungal infections are estimated to be the main cause of death for more than 1.5 million
people worldwide annually. However, fungal pathogenicity has been largely neglected. This …

Fungal secondary metabolite gliotoxin enhances enzymatic activity in soils by reshaping their microbiome

AV Teslya, EV Gurina, DV Poshvina, AA Stepanov… - Rhizosphere, 2024 - Elsevier
Gliotoxin (GT) is a sulfur-containing epidithiodioxopiperazine produced by various
filamentous fungi, including those used in biological plant protection (Trichoderma virens) …

Regulation of the Leucine Metabolism in Mortierella alpina

R Sonnabend, L Seiler, M Gressler - Journal of Fungi, 2022 - mdpi.com
The oleaginous fungus Mortierella alpina is a safe source of polyunsaturated fatty acids
(PUFA) in industrial food and feed production. Besides PUFA production, pharmaceutically …

Pleiotropic functions of SscA on the asexual spore of the human pathogenic fungus Aspergillus fumigatus

YE Son, J Han, KT Lee, HS Park - Mycology, 2024 - Taylor & Francis
Asexual spores, called conidia, are key reproductive fungal particles that enable survival in
harsh environmental conditions or host systems. The conidia can infect humans, animals …

The Transcriptome Response to Azole Compounds in Aspergillus fumigatus Shows Differential Gene Expression across Pathways Essential for Azole Resistance …

MWJ Hokken, JPM Coolen, H Steenbreker, J Zoll… - Journal of Fungi, 2023 - mdpi.com
The opportunistic pathogen Aspergillus fumigatus is found on all continents and thrives in
soil and agricultural environments. Its ability to readily adapt to novel environments and to …

The Identification of a Target Gene of the Transcription Factor KojR and Elucidation of Its Role in Carbon Metabolism for Kojic Acid Biosynthesis in Aspergillus oryzae

T Mizutani, H Oka, R Goto, R Tsurigami, J Maruyama… - Journal of Fungi, 2024 - mdpi.com
DNA-binding transcription factors are broadly characterized as proteins that bind to specific
sequences within genomic DNA and modulate the expression of downstream genes. This …