The analysis of animal models of neurological disease has been instrumental in furthering
our understanding of neurodevelopment and brain diseases. However, animal models are …

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their
differentiation into neural lineages is a revolutionary experimental system for studying …

Glutathione plays many important roles in biological processes; however, the dynamic
changes of glutathione concentrations in living cells remain largely unknown. Here, we …

Neural stem cells, the source of newborn neurons in the adult hippocampus, are intimately
involved in learning and memory, mood, and stress response. Despite considerable …

Human pluripotent stem cells offer promise for use in cell-based therapies for brain injury
and diseases. However, their cellular behavior is poorly understood. Here we show that the …

Rett syndrome (RTT) is one of the most prevalent female neurodevelopmental disorders that
cause severe mental retardation. Mutations in methyl CpG binding protein 2 (MeCP2) are …

Background Directed differentiation of human induced pluripotent stem cells (hiPSC) into
functional, region-specific neural cells is a key step to realizing their therapeutic promise to …

Human adipose-derived stem cells (hADSCs) are increasingly presumed to be a
prospective stem cell source for cell replacement therapy in various degenerative and/or …

Several protocols have been developed for human induced pluripotent stem cell neuronal
differentiation. We compare several methods for forebrain cortical neuronal differentiation by …

Human embryonic stem (hES) cells are pluripotent, capable of differentiating into any cell
type of the body, and therefore have the ability to provide insights into mechanisms of …