Mitochondria are organelles present in almost all eukaryotic cells, where they represent the
main site of energy production. Mitochondria are involved in several important cell …

The tumor niche is an environment rich in extracellular ATP (eATP) where purinergic
receptors have essential roles in different cell subtypes, including cancer, immune, and …

The NLRP3 inflammasome is a critical component of innate immunity that senses diverse
pathogen-and host-derived molecules. However, its aberrant activation has been associated …

PML assembles into nuclear domains that have attracted considerable attention from cell
and cancer biologists. Upon stress, PML nuclear bodies modulate sumoylation and other …

Purines and purinergic receptors are widely distributed throughout the human body. Purine
molecules within cells play crucial roles in regulating energy metabolism and other cellular …

Calcific aortic valve stenosis (CAVS) is among the most common causes of cardiovascular
mortality in an aging population worldwide. The pathomechanisms of CAVS are such a …

Oxidative stress refers to the imbalance between the production of reactive oxygen species
(ROS) and the endogenous antioxidant defense system. Its involvement in cell senescence …

Neuroinflammation represents a dynamic process of defense and protection against the
harmful action of infectious agents or other detrimental stimuli in the central nervous system …

Methicillin-resistant Staphylococcus aureus (MRSA) is the most common causative agent of
acute bacterial skin and skin-structure infections (ABSSSI), one of the major challenges to …

Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide.
The pathomechanisms of DKD are multifactorial, yet haemodynamic and metabolic changes …