ARPKD is a genetically inherited kidney disease that manifests by bilateral enlargement of
cystic kidneys and liver fibrosis. It shows a range of severity, with 30% of individuals dying …

Both inherited and sporadic mutations can give rise to a plethora of human diseases.
Through myriad diverse cellular processes, sporadic mutations can arise through a failure to …

The transcription factor ASCIZ (ATMIN, ZNF822) has an unusually high number of
recognition motifs for the product of its main target gene, the hub protein LC8 (DYNLL1) …

The wide distribution and diverse varieties of chickens make them important models for
studying genetic adaptation. The aim of this study was to identify genes that alter heat …

Chronic kidney disease (CKD) encompasses a group of diverse diseases that are
associated with accumulating kidney damage and a decline in glomerular filtration rate …

Abstract Autosomal Recessive Polycystic Kidney Disease (ARPKD) is a genetic disorder
with an incidence of~ 1: 20,000 that manifests in a wide range of renal and liver disease …

The orientation of cells in two-dimensional and three-dimensional space underpins how the
kidney develops and responds to disease. The process by which cells orientate themselves …

Defects in blood development frequently occur among syndromic congenital anomalies.
Thrombocytopenia-Absent Radius (TAR) syndrome is a rare congenital condition with …

Defects in blood development frequently occur among syndromic congenital anomalies.
Thrombocytopenia-Absent Radius (TAR) syndrome is a rare congenital condition with …

Biomarkers, the measurable indicators of biological conditions, are fast becoming a popular
approach in providing information to track disease processes that could lead to novel …