Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

In the 20th century, researchers studying animal and plant signaling pathways discovered a
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …

Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It serves
both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying …

Axonal degeneration is an early and prominent feature of many neurological disorders.
SARM1 is the central executioner of the axonal degeneration pathway that culminates in …

Pathological degeneration of axons disrupts neural circuits and represents one of the
hallmarks of neurodegeneration,,–. Sterile alpha and Toll/interleukin-1 receptor motif …

NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and
maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded …

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and is a risk
factor for dementia later in life. Research into the pathophysiology of TBI has focused on the …