Integral membrane proteins (IMPs) fulfill important physiological functions by providing cell–
environment, cell–cell and virus–host communication; nutrients intake; export of toxic …

Pulsed electron spin resonance (ESR) dipolar spectroscopy (PDS) in combination with site-
directed spin labeling is unique in providing nanometer-range distances and distributions in …

Solute carriers (SLC) that transport amino acids are key players in health and diseases in
humans. Their prokaryotic relatives are often involved in essential physiological processes …

Electron paramagnetic resonance (EPR) has become an important tool to probe
conformational changes in nucleic acids. An array of EPR labels for nucleic acids are …

The Na+-coupled betaine symporter BetP senses changes in the membrane state and
increasing levels of cytoplasmic K+ during hyperosmotic stress latter via its C-terminal …

Cells control their volume through the accumulation of compatible solutes. The bacterial ATP-
binding cassette transporter OpuA couples compatible solute uptake to ATP hydrolysis …

Cellular membranes and associated proteins play critical physiological roles in organisms
from all life kingdoms. In many cases, malfunction of biological membranes triggered by …

Several polytopic α-helical membrane-integrated proteins appear to be organized in higher-
ordered oligomeric complexes. While many aspects are still enigmatic, in recent years, the …

Paramagnetic (open-shell) systems, including transition metal ions, radical intermediates
and defect centres, are often involved in catalytic transformations. Despite the prevalence of …

During their mechanistic cycles membrane transporters often undergo extensive
conformational changes, sampling a range of orientations, in order to complete their …