Mesenchymal stem cell therapy for the treatment of traumatic brain injury: progress and prospects

M Das, K Mayilsamy, SS Mohapatra… - Reviews in the …, 2019 - degruyter.com
Traumatic brain injury (TBI) is a major cause of injury-related mortality and morbidity in the
USA and around the world. The survivors may suffer from cognitive and memory deficits …

[HTML][HTML] Mesenchymal stromal cell secretome for traumatic brain injury: Focus on immunomodulatory action

F Pischiutta, E Caruso, H Cavaleiro, AJ Salgado… - Experimental …, 2022 - Elsevier
The severity and long-term consequences of brain damage in traumatic brain injured (TBI)
patients urgently calls for better neuroprotective/neuroreparative strategies for this …

Stem cell therapy for neurological disorders: A focus on aging

H Nguyen, S Zarriello, A Coats, C Nelson… - Neurobiology of …, 2019 - Elsevier
Age-related neurological disorders continue to pose a significant societal and economic
burden. Aging is a complex phenomenon that affects many aspects of the human body …

Effect of brain-derived neurotrophic factor on the neurogenesis and osteogenesis in bone engineering

Q Liu, L Lei, T Yu, T Jiang, Y Kang - Tissue Engineering Part A, 2018 - liebertpub.com
During bone growth, the lack of a neuralized vascular network in the regenerating area can
affect subsequent bone quality. This study aimed to investigate if brain-derived neurotrophic …

Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury

J Hu, L Chen, X Huang, K Wu, S Ding, W Wang… - Stem cell research & …, 2019 - Springer
Background Studies have shown that transplantation of bone marrow-derived mesenchymal
stem cells (BMSCs) protects against brain damage. However, the low survival number of …

MiRNAs mediate GDNF-induced proliferation and migration of glioma cells

BL Zhang, FL Dong, TW Guo, XH Gu… - Cellular Physiology and …, 2018 - karger.com
Abstract Background/Aims: Glial cell line-derived neurotrophic factor (GDNF) is an important
factor promoting invasive glioma growth. This study was performed to reveal a unique …

Traumatic brain injury and stem cell: pathophysiology and update on recent treatment modalities

C Reis, V Gospodarev, H Reis… - Stem cells …, 2017 - Wiley Online Library
Traumatic brain injury (TBI) is a complex condition that presents with a wide spectrum of
clinical symptoms caused by an initial insult to the brain through an external mechanical …

Mesenchymal stromal cell secretome as a therapeutic strategy for traumatic brain injury

SA Muhammad - BioFactors, 2019 - Wiley Online Library
Traumatic brain injury (TBI) is a global health problem that is a common cause of disability
and mortality. Despite the availability of many treatment options, none is capable of restoring …

Bone marrow mesenchymal stem cell transplantation increases GAP-43 expression via ERK1/2 and PI3K/Akt pathways in intracerebral hemorrhage

J Cui, C Cui, Y Cui, R Li, H Sheng, X Jiang… - Cellular Physiology and …, 2017 - karger.com
Abstract Background/Aims: Intracerebral hemorrhage (ICH) occurs in hypertensive patients
and results in high rates of mortality and disability. This study determined whether bone …

Genetically engineered neural stem cells (NSCs) therapy for neurological diseases; state‐of‐the‐art

G Lutfi Ismaeel, OJ Makki AlHassani… - Biotechnology …, 2023 - Wiley Online Library
Neural stem cells (NSCs) are multipotent stem cells with remarkable self‐renewal potential
and also unique competencies to differentiate into neurons, astrocytes, and …