Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses

K Peng, Y Zheng, W Xia, ZW Mao - Chemical Society Reviews, 2023 - pubs.rsc.org
The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …

Recent advances in gold–NHC complexes with biological properties

M Mora, MC Gimeno, R Visbal - Chemical Society Reviews, 2019 - pubs.rsc.org
This tutorial review covers the recent advances made in the study of gold complexes
containing N-heterocyclic carbene ligands with biological properties. The great stability …

Aptamer chemistry

P Röthlisberger, M Hollenstein - Advanced drug delivery reviews, 2018 - Elsevier
Aptamers are single-stranded DNA or RNA molecules capable of tightly binding to specific
targets. These functional nucleic acids are obtained by an in vitro Darwinian evolution …

Riding the metal wave: A review of the latest developments in metal-based anticancer agents

S Abdolmaleki, A Aliabadi, S Khaksar - Coordination Chemistry Reviews, 2024 - Elsevier
Metal-based complexes have demonstrated significant anticancer effects and have emerged
as candidates with great potential for cancer therapy. These agents are effective in a variety …

Programmable and multifunctional DNA‐based materials for biomedical applications

Y Zhang, J Tu, D Wang, H Zhu, SK Maity… - Advanced …, 2018 - Wiley Online Library
DNA encodes the genetic information; recently, it has also become a key player in material
science. Given the specific Watson–Crick base‐pairing interactions between only four types …

Aptamer-based targeted drug delivery systems: current potential and challenges

F He, N Wen, D Xiao, J Yan, H Xiong… - Current medicinal …, 2020 - ingentaconnect.com
Aptamers are single-stranded DNA or RNA with 20-100 nucleotides in length that can
specifically bind to target molecules via formed three-dimensional structures. These …

Anticancer metal-N-heterocyclic carbene complexes of gold, platinum and palladium

T Zou, CN Lok, PK Wan, ZF Zhang, SK Fung… - Current opinion in …, 2018 - Elsevier
Highlights•Metal-NHC complexes have their metal centers stabilized under physiological
conditions and can exhibit anticancer activity.•Metal-NHC complexes having new …

New insights in Au-NHCs complexes as anticancer agents

M Porchia, M Pellei, M Marinelli, F Tisato… - European journal of …, 2018 - Elsevier
Within the research field of antitumor metal-based agents alternative to platinum drugs, gold
(I/III) coordination complexes have always been in the forefront due mainly to the familiarity …

[HTML][HTML] Recent progress of aptamer‒drug conjugates in cancer therapy

J He, Q Duan, C Ran, T Fu, Y Liu, W Tan - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Aptamers are single-stranded DNA or RNA sequences that can specifically bind with the
target protein or molecule via specific secondary structures. Compared to antibody-drug …

Recent advances in design of fluorescence-based assays for high-throughput screening

X Fang, Y Zheng, Y Duan, Y Liu, W Zhong - Analytical chemistry, 2018 - ACS Publications
Significant improvements in disease management have been achieved in the past few
decades. Using cancer as an example, survival rates have increased dramatically in …