▪ Abstract Neonicotinoids, the most important new class of synthetic insecticides of the past
three decades, are used to control sucking insects both on plants and on companion …

Imidacloprid is increasingly used worldwide as an insecticide. It is an agonist at nicotinic
acetylcholine receptors (nAChRs) and shows selective toxicity for insects over vertebrates …

Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …

The structure of the Staphylococcus aureus α-hemolysin pore has been determined to 1.9 Å
resolution. Contained within the mushroom-shaped homo-oligomeric heptamer is a solvent …

Defects in iron absorption and utilization lead to iron deficiency and overload disorders.
Adult mammals absorb iron through the duodenum, whereas embryos obtain iron through …

γ-Aminobutyrate (GABA) is a major inhibitory neurotransmitter in the adult mammalian brain.
GABA is also considered to be a multifunctional molecule that has different situational …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

The conversion of acetylcholine binding into ion conduction across the membrane is
becoming more clearly understood in terms of the structure of the receptor and its transitions …

Binding, gating, a nity and e cacy Page 1 SEMINAR Binding, gating, a nity and e cacy The nature
of the problem Some history The classical era The interaction between binding and conformation …

Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …