Liver regeneration: biological and pathological mechanisms and implications

GK Michalopoulos, B Bhushan - Nature reviews Gastroenterology & …, 2021 - nature.com
The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

[PDF][PDF] Hepatostat: Liver regeneration and normal liver tissue maintenance

GK Michalopoulos - Hepatology, 2017 - Wiley Online Library
In contrast to all other organs, liver‐to‐body‐weight ratio needs to be maintained always at
100% of what is required for body homeostasis. Adjustment of liver size to 100% of what is …

Liver regeneration

GK Michalopoulos - The liver: biology and pathobiology, 2020 - Wiley Online Library
Signals related to liver regeneration (LR) have been identified by triggering proliferation in
hepatocyte cultures, delay of regeneration associated with signal ablation in genomically …

Principles of liver regeneration and growth homeostasis

GK Michalopoulos - Comprehensive physiology, 2013 - Wiley Online Library
Liver regeneration is perhaps the most studied example of compensatory growth aimed to
replace loss of tissue in an organ. Hepatocytes, the main functional cells of the liver, manage …

Role of growth factors and cytokines in hepatic regeneration

N Fausto, AD Laird, EM Webber - The FASEB Journal, 1995 - Wiley Online Library
During liver regeneration quiescent hepatocytes undergo one or two rounds of replication
and then return to a nonproliferative state. Growth factors regulate this process by providing …

Preoperative portal vein embolization for extension of hepatectomy indications

T de Baere, A Roche, D Elias, P Lasser, C Lagrange… - Hepatology, 1996 - journals.lww.com
To render hepatectomy feasible in patients with an initially deficient volume of the future
remnant liver (FRL), we redistributed portal blood flow rich in hepatotrophic substances …

[图书][B] Transplantation of the liver

RW Busuttil, GB Klintmalm - 2014 - books.google.com
Drs. Busuttil and Klintmalm present Transplantation of the Liver, 3rd Edition, which has been
thoroughly revised to offer you the latest protocols, surgical approaches, and techniques …

Signals and cells involved in regulating liver regeneration

LI Kang, WM Mars, GK Michalopoulos - Cells, 2012 - mdpi.com
Liver regeneration is a complex phenomenon aimed at maintaining a constant liver mass in
the event of injury resulting in loss of hepatic parenchyma. Partial hepatectomy is followed …

Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biologically active recombinant ALR and demonstration of tissue …

M Hagiya, A Francavilla, L Polimeno… - Proceedings of the …, 1994 - National Acad Sciences
A full-length cDNA clone encoding a purified augmenter of liver regeneration (ALR) factor
prepared from the cytosol of weanling rat livers was isolated. The 1.2-kb cDNA included a …

In vivoresponse of hepatocytes to growth factors requires an initial priming stimulus

EM Webber, PJ Godowski, N Fausto - Hepatology, 1994 - journals.lww.com
Although growth factor effects have been studied in cultured hepatocytes, little information
exists as to whether these factors can trigger hepatocyte replication in vivo. In this study we …