Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis

QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Circadian rhythm disturbances in mood disorders: insights into the role of the suprachiasmatic nucleus

CA Vadnie, CA McClung - Neural plasticity, 2017 - Wiley Online Library
Circadian rhythm disturbances are a common symptom among individuals with mood
disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior …

De novo mutations in ATP1A3 cause alternating hemiplegia of childhood

EL Heinzen, KJ Swoboda, Y Hitomi, F Gurrieri… - Nature …, 2012 - nature.com
Alternating hemiplegia of childhood (AHC) is a rare, severe neurodevelopmental syndrome
characterized by recurrent hemiplegic episodes and distinct neurological manifestations …

α‐synuclein assemblies sequester neuronal α3‐Na+/K+‐ATPase and impair Na+ gradient

AN Shrivastava, V Redeker, N Fritz, L Pieri… - The EMBO …, 2015 - embopress.org
Extracellular α‐synuclein (α‐syn) assemblies can be up‐taken by neurons; however, their
interaction with the plasma membrane and proteins has not been studied specifically. Here …

Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models

I Aiba, JL Noebels - Science translational medicine, 2015 - science.org
Cardiorespiratory collapse after a seizure is the leading cause of sudden unexpected death
in epilepsy (SUDEP) in young persons, but why only certain individuals are at risk is …

[HTML][HTML] Brain Na+, K+-ATPase activity in aging and disease

GR de Lores Arnaiz, MGL Ordieres - International journal of …, 2014 - ncbi.nlm.nih.gov
Na+/K+ pump or sodium-and potassium-activated adenosine 5'-triphosphatase (Na+, K+-
ATPase), its enzymatic version, is a crucial protein responsible for the electrochemical …

Distinct neurological disorders with ATP1A3 mutations

EL Heinzen, A Arzimanoglou, A Brashear… - The Lancet …, 2014 - thelancet.com
Genetic research has shown that mutations that modify the protein-coding sequence of
ATP1A3, the gene encoding the α 3 subunit of Na+/K+-ATPase, cause both rapid-onset …

The neural substrates of rapid-onset Dystonia-Parkinsonism

DP Calderon, R Fremont, F Kraenzlin… - Nature …, 2011 - nature.com
Although dystonias are a common group of movement disorders, the mechanisms by which
brain dysfunction results in dystonia are not understood. Rapid-onset Dystonia …

Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2

L Leo, L Gherardini, V Barone, M De Fusco… - PLoS …, 2011 - journals.plos.org
Familial hemiplegic migraine type 2 (FHM2) is an autosomal dominant form of migraine with
aura that is caused by mutations of the α2-subunit of the Na, K-ATPase, an isoform almost …

Mapping genetic modifiers of survival in a mouse model of Dravet syndrome

AR Miller, NA Hawkins, CE McCollom… - Genes, Brain and …, 2014 - Wiley Online Library
Epilepsy is a common neurological disorder affecting approximately 1% of the population.
Mutations in voltage‐gated sodium channels are responsible for several monogenic …