A renewed concept on the MAPK signaling pathway in cancers: Polyphenols as a choice of therapeutics
Abnormalities in the mitogen-activated protein kinase (MAPK) signaling pathway are a key
contributor to the carcinogenesis process and have therefore been implicated in several …
contributor to the carcinogenesis process and have therefore been implicated in several …
Anti-cancer potential of cannabinoids, terpenes, and flavonoids present in cannabis
AM Tomko, EG Whynot, LD Ellis, DJ Dupré - Cancers, 2020 - mdpi.com
In recent years, and even more since its legalization in several jurisdictions, cannabis and
the endocannabinoid system have received an increasing amount of interest related to their …
the endocannabinoid system have received an increasing amount of interest related to their …
Flavonoids as an effective sensitizer for anti-cancer therapy: Insights into multi-faceted mechanisms and applicability towards individualized patient profiles
Cost-efficacy of currently applied treatments is an issue in overall cancer management
challenging healthcare and causing tremendous economic burden to societies around the …
challenging healthcare and causing tremendous economic burden to societies around the …
Nrf2 signaling pathway in chemoprotection and doxorubicin resistance: potential application in drug discovery
Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …
Rationalizing the therapeutic potential of apigenin against cancer
Background Despite the remarkable advances made in the diagnosis and treatment of
cancer during the past couple of decades, it remains the second largest cause of mortality in …
cancer during the past couple of decades, it remains the second largest cause of mortality in …
Therapeutical properties of apigenin: A review on the experimental evidence and basic mechanisms
ABSTRACT Apigenin (4,'5, 7-trihydroxyflavone) is one of the most studied flavonoids with
low toxicity and abundantly present phenolic compound in the plant kingdom. The main …
low toxicity and abundantly present phenolic compound in the plant kingdom. The main …
Pharmacological properties of 4′, 5, 7-Trihydroxyflavone (apigenin) and its impact on cell signaling pathways
Plant bioactive compounds, particularly apigenin, have therapeutic potential and functional
activities that aid in the prevention of infectious diseases in many mammalian bodies and …
activities that aid in the prevention of infectious diseases in many mammalian bodies and …
Role of induced programmed cell death in the chemopreventive potential of apigenin
JY Jang, B Sung, ND Kim - International Journal of Molecular Sciences, 2022 - mdpi.com
The flavonoid apigenin (4′, 5, 7-trihydroxyflavone), which is one of the most widely
distributed phytochemicals in the plant kingdom, is one of the most thoroughly investigated …
distributed phytochemicals in the plant kingdom, is one of the most thoroughly investigated …
Chemoprotective and chemosensitizing effects of apigenin on cancer therapy
Background Therapeutic resistance to radiation and chemotherapy is one of the major
obstacles in cancer treatment. Although synthetic radiosensitizers are pragmatic solution to …
obstacles in cancer treatment. Although synthetic radiosensitizers are pragmatic solution to …
Power of two: combination of therapeutic approaches involving glucose transporter (GLUT) inhibitors to combat cancer
Cancer research of the Warburg effect, a hallmark metabolic alteration in tumors, focused
attention on glucose metabolism whose targeting uncovered several agents with promising …
attention on glucose metabolism whose targeting uncovered several agents with promising …