Cerebral cavernous malformations are acquired vascular anomalies that constitute a
common cause of central nervous system hemorrhage and stroke. The past 2 decades have …

Cellular homeostasis is continuously challenged by environmental cues and cellular stress
conditions. In their defense, cells need to mount appropriate stress responses that …

To elucidate the pathogenesis of vein of Galen malformations (VOGMs), the most common
and most severe of congenital brain arteriovenous malformations, we performed an …

Cerebral cavernous malformations (CCMs) are a neurovascular anomaly that may occur
sporadically or be inherited due to autosomal dominant mutations in KRIT1, CCM2 or …

Cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations
(SCCMs) are common vascular abnormalities of the CNS that can lead to seizure …

A high tumor mutation burden (TMB) is known to drive the response to immune checkpoint
inhibitors (ICI) and is associated with favorable prognoses. However, because it is a one …

Extra-axial cavernous hemangiomas (ECHs) are complex vascular lesions mainly found in
the spine and cavernous sinus. Their removal poses significant risk due to their vascularity …

PIK3CA-related overgrowth spectrum (PROS) disorders are caused by somatic mosaic
variants that result in constitutive activation of the phosphatidylinositol-3-kinase/AKT/mTOR …

PIK3CA pathogenic variants are responsible for a group of overgrowth syndromes,
collectively known as PIK3CA-Related Overgrowth Spectrum (PROS). These gain-of …

Cerebral cavernous malformations (CCMs) are abnormally dilated intracranial capillaries
that form cerebrovascular lesions with a high risk of hemorrhagic stroke. Recently, several …