Schistosoma “eggs-iting” the host: granuloma formation and egg excretion

C Schwartz, PG Fallon - Frontiers in immunology, 2018 - frontiersin.org
Schistosomiasis is a major cause of morbidity in humans invoked by chronic infection with
parasitic trematodes of the genus Schistosoma. Schistosomes have a complex life-cycle …

Immune evasion strategies of schistosomes

JR Hambrook, PC Hanington - Frontiers in immunology, 2021 - frontiersin.org
Human schistosomes combat the unique immune systems of two vastly different hosts
during their indirect life cycles. In gastropod molluscs, they face a potent innate immune …

Enolase: a key player in the metabolism and a probable virulence factor of trypanosomatid parasites—perspectives for its use as a therapeutic target

L Avilán, M Gualdrón-López, W Quiñones… - Enzyme …, 2011 - Wiley Online Library
Glycolysis and glyconeogenesis play crucial roles in the ATP supply and synthesis of
glycoconjugates, important for the viability and virulence, respectively, of the human …

Interference with the host haemostatic system by schistosomes

MM Mebius, PJJ van Genderen, RT Urbanus… - PLoS …, 2013 - journals.plos.org
Schistosomes, parasitic flatworms that cause the tropical disease schistosomiasis, are still a
threat. They are responsible for 200 million infections worldwide and an estimated 280,000 …

Schistosomes enhance plasminogen activation: the role of tegumental enolase

BC Figueiredo, AA Da'dara, SC Oliveira… - PLoS …, 2015 - journals.plos.org
Schistosoma mansoni is a blood fluke parasite that causes schistosomiasis, a debilitating
disease of global public health importance. These relatively large parasites are able to …

Numerous Fasciola plasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the …

J González-Miguel, MA Valero, M Reguera-Gomez… - Parasitology, 2019 - cambridge.org
Human fascioliasis is a worldwide, pathogenic food-borne trematodiasis. Impressive clinical
pictures comprising puzzling polymorphisms, manifestation multifocality, disease evolution …

Identification and Analysis of the Tegument Protein and Excretory-Secretory Products of the Carcinogenic Liver Fluke Clonorchis sinensis

Y Shi, K Yu, A Liang, Y Huang, F Ou, H Wei… - Frontiers in …, 2020 - frontiersin.org
Liver fluke proteins, including excretory-secretory products (ESPs) and tegument proteins,
are critical for the pathogenesis, nutrient metabolism, etiology and immune response of liver …

Parasitism in optima forma: exploiting the host fibrinolytic system for invasion

L Figuera, A Gómez-Arreaza, L Avilán - Acta Tropica, 2013 - Elsevier
The interaction of pathogenic bacteria with the host fibrinolytic system through the
plasminogen molecule has been well documented. It has been shown, using animal …

Schistosoma mansoni: the egg, biosynthesis of the shell and interaction with the host

S deWalick, AGM Tielens, JJ van Hellemond - Experimental parasitology, 2012 - Elsevier
The schistosome eggshell is a hardened and tanned structure made from cross-linked
proteins. It is synthesized within the female worm from many different kinds of proteins and …

Clonorchis sinensis enolase: identification and biochemical characterization of a glycolytic enzyme from excretory/secretory products

X Wang, W Chen, F Hu, C Deng, C Zhou, X Lv… - Molecular and …, 2011 - Elsevier
Enolase plays a key role in energy metabolism and development of most organisms. We
isolated a gene encoding enolase from Clonorchis sinensis (C. sinensis) adult cDNA library …