One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and
neurotransmitter release, and elicit the plasticity and growth of axons within the adult central …

After injury to the adult central nervous system (CNS), injured axons cannot regenerate past
the lesion. In this review, we present evidence that this is due to the formation of a glial scar …

The inability of axons to regenerate after a spinal cord injury in the adult mammalian central
nervous system (CNS) can lead to permanent paralysis. At sites of CNS injury, a glial scar …

Members of the nerve growth factor (NGF) and glial cell line-derived neurotrophic factor
(GDNF) families—comprising neurotrophins and GDNF-family ligands (GFLs), respectively …

▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …

Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

The therapy of neural nerve injuries that involve the disruption of axonal pathways or axonal
tracts has taken a new dimension with the development of tissue engineering techniques …

▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …