Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Abstract Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004;
10.1152/physrev. 00014.2003.—One of the most significant challenges in neuroscience is to …

▪ Abstract ADARs are RNA editing enzymes that target double-stranded regions of nuclear-
encoded RNA and viral RNA. These enzymes are particularly abundant in the nervous …

Excitotoxicity is one of the most extensively studied processes of neuronal cell death, and
plays an important role in many central nervous system (CNS) diseases, including CNS …

We focus on emerging roles for microglia in synaptic plasticity, cognition and disease. We
outline evidence that ramified microglia, traditionally thought to be functionally “resting”(ie …

Two decades have passed since the first report of the cloning of a kainate-type glutamate
receptor (KAR) subunit. The intervening years have seen a rapid growth in our …

RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are comprised of
different combinations of GluA1–GluA4 (also known asGluR1–GluR4 and GluR-A to GluR …

Functional kainate receptors are ubiquitous in the central nervous system. After a search for
their functional significance, a considerable amount of data indicates that this class of …

Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second
messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene …