Advanced drug delivery systems and artificial skin grafts for skin wound healing
Cutaneous injuries, especially chronic wounds, burns, and skin wound infection, require
painstakingly long-term treatment with an immense financial burden to healthcare systems …
painstakingly long-term treatment with an immense financial burden to healthcare systems …
The future of stem cell therapies for Parkinson disease
M Parmar, S Grealish, C Henchcliffe - Nature Reviews Neuroscience, 2020 - nature.com
Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …
Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience
The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …
ability to study complex human neurological disorders and elucidate basic neuroscientific …
More than bad luck: cancer and aging are linked to replication-driven changes to the epigenome
CJ Minteer, K Thrush, J Gonzalez, P Niimi… - Science …, 2023 - science.org
Aging is a leading risk factor for cancer. While it is proposed that age-related accumulation
of somatic mutations drives this relationship, it is likely not the full story. We show that aging …
of somatic mutations drives this relationship, it is likely not the full story. We show that aging …
The pluripotent state in mouse and human
KC Davidson, EA Mason, MF Pera - Development, 2015 - journals.biologists.com
In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture
equivalent of the late epiblast in the pre-implantation embryo, with which they share a …
equivalent of the late epiblast in the pre-implantation embryo, with which they share a …
Cell culture‐derived extracellular vesicles: Considerations for reporting cell culturing parameters
Cell culture‐conditioned medium (CCM) is a valuable source of extracellular vesicles (EVs)
for basic scientific, therapeutic and diagnostic applications. Cell culturing parameters affect …
for basic scientific, therapeutic and diagnostic applications. Cell culturing parameters affect …
A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells
Human pluripotent stem cells (hPSCs) are capable of extensive self-renewal yet remain
highly sensitive to environmental perturbations in vitro, posing challenges to their …
highly sensitive to environmental perturbations in vitro, posing challenges to their …
Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions
O Thompson, F von Meyenn, Z Hewitt… - Nature …, 2020 - nature.com
The occurrence of repetitive genomic changes that provide a selective growth advantage in
pluripotent stem cells is of concern for their clinical application. However, the effect of …
pluripotent stem cells is of concern for their clinical application. However, the effect of …
How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …
scientific and medical advances, clinically effective regenerative therapies including stem …
Distinct metabolic states can support self-renewal and lipogenesis in human pluripotent stem cells under different culture conditions
Recent studies have suggested that human pluripotent stem cells (hPSCs) depend primarily
on glycolysis and only increase oxidative metabolism during differentiation. Here, we …
on glycolysis and only increase oxidative metabolism during differentiation. Here, we …