The holy grail of epilepsy prevention: Preclinical approaches to antiepileptogenic treatments

W Löscher - Neuropharmacology, 2020 - Elsevier
A variety of acute brain insults can induce epileptogenesis, a complex process that results in
acquired epilepsy. Despite advances in understanding mechanisms of epileptogenesis …

Traumatic brain injury: Mechanisms, manifestations, and visual sequelae

SH Rauchman, A Zubair, B Jacob… - Frontiers in …, 2023 - frontiersin.org
Traumatic brain injury (TBI) results when external physical forces impact the head with
sufficient intensity to cause damage to the brain. TBI can be mild, moderate, or severe and …

[HTML][HTML] Traumatic brain injury and epilepsy: underlying mechanisms leading to seizure

BP Lucke-Wold, L Nguyen, RC Turner, AF Logsdon… - Seizure, 2015 - Elsevier
Post-traumatic epilepsy continues to be a major concern for those experiencing traumatic
brain injury. Post-traumatic epilepsy accounts for 10–20% of epilepsy cases in the general …

Dogs as a natural animal model of epilepsy

W Löscher - Frontiers in veterinary science, 2022 - frontiersin.org
Epilepsy is a common neurological disease in both humans and domestic dogs, making
dogs an ideal translational model of epilepsy. In both species, epilepsy is a complex brain …

Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions

VM Golub, DS Reddy - Pharmacological reviews, 2022 - ASPET
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …

Canine epilepsy as a translational model?

H Potschka, A Fischer, EL von Rüden, V Hülsmeyer… - …, 2013 - Wiley Online Library
Dogs with spontaneous diseases can exhibit a striking similarity in etiology, clinical
manifestation, and disease course when compared to human patients. Therefore, dogs are …

The short form of the Glasgow composite measure pain scale in post-operative analgesia studies in dogs: a scoping review

B Testa, J Reid, ME Scott, PJ Murison… - Frontiers in Veterinary …, 2021 - frontiersin.org
The measurement and treatment of acute pain in animals is essential from a welfare
perspective. Valid pain-related outcome measures are also crucial for ensuring reliable and …

Seizure occurrence in dogs under primary veterinary care in the UK: prevalence and risk factors

A Erlen, H Potschka, HA Volk… - Journal of veterinary …, 2018 - Wiley Online Library
Background Primary‐care veterinary clinical records can offer data to determine
generalizable epidemiological data on seizures occurrence in the dog population …

The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy

C Rundfeldt, W Löscher - CNS drugs, 2014 - Springer
Although benzodiazepines (BZDs) offer a wide spectrum of antiepileptic activity against
diverse types of epileptic seizures, their use in the treatment of epilepsy is limited because of …

Clinical efficacy and safety of imepitoin in comparison with phenobarbital for the control of idiopathic epilepsy in dogs

A Tipold, TJ Keefe, W Löscher… - Journal of veterinary …, 2015 - Wiley Online Library
The anticonvulsant activity and safety of imepitoin, a novel antiepileptic drug licensed in the
E uropean U nion, were evaluated in a multicentre field efficacy study as well as in a safety …