Extracellular matrix (ECM) is a complex network of macromolecules such as proteoglycans
(PGs), glycosaminoglycans (GAGs) and fibrous proteins present within all tissues and …

Cancer is a multifaceted and complex pathology characterized by uncontrolled cell
proliferation and decreased apoptosis. Most cancers are recognized by an inflammatory …

Hyaluronan (HA) is a linear glycosaminoglycan (GAG) of extracellular matrix (ECM)
synthesized by three hyaluronan synthases (HASes) at the plasma membrane using uridine …

Solid cancers such as breast tumors comprise a collection of tumor, stromal and immune
cells, embedded within a network of tumor-specific extracellular matrix. This matrix is …

The hyaluronan (HA) polymer is an important macromolecule of extracellular matrix with
remarkable structure and functions: it is a linear and unbranched polymer without sulphate …

Mammalian glycosaminoglycans (GAGs), except hyaluronan (HA), are sulfated
polysaccharides that are covalently attached to core proteins to form proteoglycans (PGs) …

Hyaluronan (HA) is one of the most prevalent glycosaminoglycans of the vascular
extracellular matrix (ECM). Abnormal HA accumulation within blood vessel walls is …

Over the last few decades, scientists have recognized the critical role that various
components of the extracellular matrix (ECM) play in maintaining homeostatic immunity …

In antineoplastic therapy, one of the challenges is to adjust the treatment to the needs of
each patient and reduce the toxicity caused by conventional antitumor strategies. It has been …

Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical
factor in regulating both the repair of tissue injuries and the progression of diseases such as …