Rhythmic and effective cardiac contraction depends on appropriately timed generation and
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …

Ventricular tachycardia in nonischemic heart failure (HF) initiates by a nonreentrant
mechanism that appears to be due to triggered activity primarily from delayed …

The inward rectifier current I K1 is tightly regulated regionally within the heart,
downregulated in heart failure, and genetically suppressed in Andersen syndrome. We used …

Normal cardiac function requires an appropriate and regular beating rate (cardiac rhythm).
When the heart rhythm is too fast or too slow, cardiac function can be impaired, with …

OBJECTIVES: This study was designed to determine whether ionic currents in right
ventricular myocytes from explanted human transplant recipient hearts are related to right …

Congestive heart failure is the leading cause of death in the Western world. Abnormal
intracellular calcium (Ca2+) handling is central to the pathogenesis of heart failure because …

Cardiac rhythm disorders reflect failures of impulse generation and/or conduction. With the
exception of ablation methods that yield selective endocardial destruction, present therapies …

Due to its varied and variable phenotypes, Andersen‐Tawil syndrome (ATS) holds a unique
place in the field of channelopathies. Patients with ATS typically present with the triad of …

Ventricular arrhythmia is the most common cause of sudden cardiac death in patients with
myocardial infarction (MI). Fibroblast growth factor 21 (FGF21) has been shown to play an …

Background—Human (h) embryonic stem cells (ESCs) and induced pluripotent stem cells
(iPSCs) serve as a potential unlimited ex vivo source of cardiomyocytes (CMs). However, a …