Comprehensive Review of Uterine Leiomyosarcoma: Pathogenesis, Diagnosis, Prognosis, and Targeted Therapy
Q Yang, OS Madueke-Laveaux, H Cun, M Wlodarczyk… - Cells, 2024 - mdpi.com
Uterine leiomyosarcoma (uLMS) is the most common subtype of uterine sarcomas. They
have a poor prognosis with high rates of recurrence and metastasis. The five-year survival …
have a poor prognosis with high rates of recurrence and metastasis. The five-year survival …
Epigenetic features in uterine leiomyosarcoma and endometrial stromal sarcomas: an overview of the literature
There is a consensus that epigenetic alterations play a key role in cancer initiation and its
biology. Studies evaluating the modification in the DNA methylation and chromatin …
biology. Studies evaluating the modification in the DNA methylation and chromatin …
Bromodomain-containing protein 9 regulates signaling pathways and reprograms the epigenome in immortalized human uterine fibroid cells
Bromodomain-containing proteins (BRDs) are involved in many biological processes, most
notably epigenetic regulation of transcription, and BRD dysfunction has been linked to many …
notably epigenetic regulation of transcription, and BRD dysfunction has been linked to many …
Targeting class I histone deacetylases in human uterine leiomyosarcoma
Uterine leiomyosarcoma (uLMS) is the most frequent subtype of uterine sarcoma that
presents a poor prognosis, high rates of recurrence, and metastasis. Currently, the …
presents a poor prognosis, high rates of recurrence, and metastasis. Currently, the …
The role of microRNAs in uterine leiomyosarcoma diagnosis and treatment
I Psilopatis, K Vrettou, S Kokkali, S Theocharis - Cancers, 2023 - mdpi.com
Simple Summary MicroRNAs (miRNAs) show differential expression in various cancer
entities and seemingly contribute to cancer development and/or progression. Nevertheless …
entities and seemingly contribute to cancer development and/or progression. Nevertheless …
Targeting SWI/SNF complexes in cancer: pharmacological approaches and implications
MR Dreier, J Walia, IL de la Serna - Epigenomes, 2024 - mdpi.com
SWI/SNF enzymes are heterogeneous multi-subunit complexes that utilize the energy from
ATP hydrolysis to remodel chromatin structure, facilitating transcription, DNA replication, and …
ATP hydrolysis to remodel chromatin structure, facilitating transcription, DNA replication, and …
[HTML][HTML] Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma
Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma, associated
with poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular …
with poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular …
Survivin-Sodium Iodide Symporter Reporter as a Non-Invasive Diagnostic Marker to Differentiate Uterine Leiomyosarcoma from Leiomyoma
Leiomyosarcoma (LMS) has been challenging to diagnose because of limitations in clinical
and radiographic predictors, as well as the lack of reliable serum or urinary biomarkers. Most …
and radiographic predictors, as well as the lack of reliable serum or urinary biomarkers. Most …
Uterine fibroids: current research on novel drug targets and innovative therapeutic strategies
M Ciebiera, J Kociuba, M Ali… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Uterine fibroids, the most common nonmalignant tumors affecting the female
genital tract, are a significant medical challenge. This article focuses on the most recent …
genital tract, are a significant medical challenge. This article focuses on the most recent …
TPPP-BRD9 fusion-related gallbladder carcinomas are frequently associated with intracholecystic neoplasia, neuroendocrine carcinoma, and a distinctive small …
A fusion between tubulin polymerization-promoting protein (TPPP), a regulatory cytoskeletal
gene, and the chromatin remodeling factor, bromodomain-containing protein 9 (BRD9) …
gene, and the chromatin remodeling factor, bromodomain-containing protein 9 (BRD9) …