Platelet-mediated tumor metastasis mechanism and the role of cell adhesion molecules

Y Liu, Y Zhang, Y Ding, R Zhuang - Critical Reviews in Oncology …, 2021 - Elsevier
Mounting evidence suggests that platelets play an essential role in cancer metastasis. The
interactions between platelets and circulating tumor cells (CTCs) promote cancer …

Emerging roles of platelets in cancer biology and their potential as therapeutic targets

L Wang, X Wang, E Guo, X Mao, S Miao - Frontiers in oncology, 2022 - frontiersin.org
The main role of platelets is to control bleeding and repair vascular damage via thrombosis.
They have also been implicated to promote tumor metastasis through platelet-tumor cell …

The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance …

G Bendas, M Schlesinger - Experimental Hematology & Oncology, 2022 - Springer
Abstract The glycoprotein (GP) Ib-IX complex is a platelet receptor that mediates the initial
interaction with subendothelial von Willebrand factor (VWF) causing platelet arrest at sites of …

Signaling mechanisms of the platelet glycoprotein Ib-IX complex

Y Zhang, SM Ehrlich, C Zhu, X Du - Platelets, 2022 - Taylor & Francis
Abstract The glycoprotein Ib–IX (GPIb-IX) complex mediates initial platelet adhesion to von
Willebrand factor (VWF) immobilized on subendothelial matrix and endothelial surfaces, and …

Platelets, constant and cooperative companions of sessile and disseminating tumor cells, crucially contribute to the tumor microenvironment

WMJ Obermann, K Brockhaus, JA Eble - Frontiers in Cell and …, 2021 - frontiersin.org
Although platelets and the coagulation factors are components of the blood system, they
become part of and contribute to the tumor microenvironment (TME) not only within a solid …

Novel causal plasma proteins for hypothyroidism: a large-scale plasma proteome Mendelian randomization analysis

H Yang, L Chen, Y Liu - The Journal of Clinical Endocrinology & …, 2023 - academic.oup.com
Context Although several risk proteins for hypothyroidism have been reported in recent
years, many more plasma proteins have not been tested. Objective To determine potential …

Distinct platelet F-actin patterns and traction forces on von Willebrand factor versus fibrinogen

MY Mollica, KM Beussman, A Kandasamy… - Biophysical …, 2023 - cell.com
Upon vascular injury, platelets form a hemostatic plug by binding to the subendothelium and
to each other. Platelet-to-matrix binding is initially mediated by von Willebrand factor (VWF) …

Research and clinical approaches to assess platelet function in flowing blood

JI Hearn, EE Gardiner - Arteriosclerosis, Thrombosis, and Vascular …, 2023 - Am Heart Assoc
Platelet adhesion and activation is fundamental to the formation of a hemostatic response to
limit loss of blood and instigate wound repair to seal a site of vascular injury. The process of …

Platelet glycoprotein-Ib (GPIb) may serve as a bridge between type 2 diabetes mellitus (T2DM) and atherosclerosis, making It a potential target for antiplatelet agents …

M Amalia, MU Puteri, FC Saputri, R Sauriasari… - Life, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a persistent metabolic condition that contributes to the
development of cardiovascular diseases. Numerous studies have provided evidence that …

Hematopoietic stem cells and extramedullary hematopoiesis in the lungs

A Reichard, N Wanner, S Farha, K Asosingh - Cytometry Part A, 2023 - Wiley Online Library
Hematopoietic stem cells are key players in hematopoiesis as the body maintains a
physiologic steady state, and the signaling pathways and control mechanisms of these …