L-5-hydroxytryptophan (5-HTP) is both a drug and a natural component of some dietary
supplements. 5-HTP is produced from tryptophan by tryptophan hydroxylase (TPH), which is …

Simple Summary Environmental light exposure is an important factor for human health that
impacts the biological clock of organisms. Melatonin usually serves as a chemical …

Abstract Melatonin (N-acetyl-5-methoxytryptamine) is an emerging biomolecule that
influences horticultural crop growth, flowering, fruit ripening, postharvest preservation, and …

Tryptophan derivatives are various aromatic compounds produced in the tryptophan
metabolic pathway, such as 5-hydroxytryptophan, 5-hydroxytryptamine, melatonin, 7-chloro …

Melatonin dietary supplements are widely consumed worldwide, with developed countries
as the largest consumers, with an estimated annual growth rate of approximately 10% until …

Melatonin is a biogenic amine that can be found in plants, animals and microorganism. The
metabolic pathway of melatonin is different in various organisms, and biosynthetic …

Abstract Melatonin (MT)(N-acetyl-5-methoxytryptamine) is an indoleamine recognized
primarily for its crucial role in regulating sleep through circadian rhythm modulation in …

Diseases caused by pathogenic bacteria in animals (eg, bacterial pneumonia, meningitis
and sepsis) and plants (eg, bacterial wilt, angular spot and canker) lead to high prevalence …

Highlights•Systems metabolic engineering has enabled efficient production of natural
products.•Systems-level engineering of metabolism has increased pathway efficiencies.•Cell …

Aromatic L-amino acid decarboxylases (AADCs) catalyze the conversion of aromatic L-
amino acids into aromatic monoamines that play diverse physiological and biosynthetic …