Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains
one of the most treatment-resistant CNS malignancies, and the tumour inevitably recurs. The …

Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive
molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has …

Abstract This investigator-initiated, phase 2, single-arm trial primarily assessed the efficacy
of G47∆, a triple-mutated, third-generation oncolytic herpes simplex virus type 1, in 19 adult …

In response to major changes in diagnostic algorithms and the publication of mature results
from various large clinical trials, the European Association of Neuro-Oncology (EANO) …

Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

The standard of care (SOC) for high-grade gliomas (HGG) is maximally safe surgical
resection, followed by concurrent radiation therapy (RT) and temozolomide (TMZ) for 6 …

Primary CNS tumours refer to a heterogeneous group of tumours arising from cells within the
CNS, and can be benign or malignant. Malignant primary brain tumours remain among the …

Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …