Disulfide-Rich Cyclic Peptides from Clitoria ternatea Protect against β-Amyloid Toxicity and Oxidative Stress in Transgenic Caenorhabditis elegans

NV Kalmankar, H Hari, R Sowdhamini… - Journal of medicinal …, 2021 - ACS Publications
Neurotoxic aggregation of β-amyloid (Aβ) peptides is a hallmark of Alzheimer's disease and
increased reactive oxygen species (ROS) is an associated process. In the present study, we …

Hijacking of N-fixing legume albumin-1 genes enables the cyclization and stabilization of defense peptides

EK Gilding, MA Jackson, LTT Nguyen… - Nature …, 2024 - nature.com
The legume albumin-1 gene family, arising after nodulation, encodes linear a-and b-chain
peptides for nutrient storage and defense. Intriguingly, in one prominent legume, Clitoria …

Cyclotides: The next generation in biopesticide development for eco‐friendly agriculture

GH Tran, TH Tran, SH Pham, HL Xuan… - Journal of Peptide …, 2024 - Wiley Online Library
Chemical pesticides remain the predominant method for pest management in numerous
countries. Given the current landscape of agriculture, the development of biopesticides has …

Integrative transcriptome and mass spectrometry analysis reveals novel cyclotides with antimicrobial and cytotoxic activities from Viola arcuata

X Tang, Q Zou, Y Yan, F He, Y Cui, Y Lian… - Plant Physiology and …, 2025 - Elsevier
Cyclotides are small plant-derived proteins synthesized by plant ribosomes. Their primary
structure features a head-to-tail cyclization stabilized by three pairs of disulfide bonds …

Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming

B Doffek, Y Huang, YH Huang, LY Chan, EK Gilding… - Phytochemistry, 2022 - Elsevier
Cyclotides are a class of ribosomally-synthesized plant peptides that function in plants as a
defense against insects and fungal pathogens. Their unique structure comprises a cyclized …

Cyclotides, Cyclic Peptides Derived from Clitoria ternatea Linn Mature Pods, Hold Promise as Potential Antimicrobial Agent

TTT Tran, GH Tran, ST Cu, SH Pham… - …, 2023 - Wiley Online Library
Cyclotides, cysteine‐rich peptides, are derived from various plant sources. Within the
Fabaceae family, Clitoria ternatea Linn distinguishes itself as the only species that has been …

LC-MS/MS identification and structural characterization of isolated cyclotides from precursor sequences of Viola odorata L. petiole tissue using computational …

L Aslam, R Kaur, S Hussain, N Kapoor… - Journal of Biosciences, 2022 - Springer
Viola odorata L., known for its pharmacological properties, produces a plethora of
structurally stable peptides called cyclotides. Cyclotides are macrocyclic peptides with a …

[HTML][HTML] Cyclotides prediction in Leptopetalum biflorum based on de novo transcriptome assembly and annotation

X Liu, L Cai, Z Zhou, P Huang, Z Ren - Journal of Holistic Integrative …, 2024 - Elsevier
Objective There is a scarcity of transcriptome sequencing data available for the
Leptopetalum biflorum, and numerous cyclotides remain undiscovered. It is urgent to …

RNA Sequencing Approach for Genome-Wide Transcriptome Profiling in Ethnomedicinal Plants

R Chandrakanth, L Sunil, Sadashivaiah - Ethnomedicinal Plants for Drug …, 2024 - Springer
Ethnomedicinal plants are species of plants traditionally used by indigenous cultures for
medicinal purposes. These plants have been an important source of natural remedies for …

Genome-wide in silico and in vitro mining to develop a novel cyclotide-based marker system in plants

A Salah, EA El-Khateeb, RM Gaafar… - Biotechnology & …, 2023 - Taylor & Francis
Cyclotides are cysteine-rich cyclic peptides that have various activities and applications.
Mining at the whole-genome scale facilitates the profiling and development of cyclotide …