Myocardial fibrosis (MF) represents the underlying pathologic condition of many cardiac
disease, leading to cardiac dysfunction and heart failure (HF). Biopsy studies have shown …

In patients with aortic and/or mitral valve disease the presence of pulmonary hypertension
(PH) indicates a decompensated state of the disease with left ventricular and left atrial …

Pressure overload causes cardiac fibroblast activation and transdifferentiation, leading to
increased interstitial fibrosis formation and subsequently myocardial stiffness, diastolic and …

Background The role of left atrial (LA) strain as an imaging biomarker in aortic stenosis is not
well established. The aim of this study was to investigate the prognostic performance of …

Aims Individuals with supranormal left ventricular ejection fraction (snLVEF; LVEF> 70%)
have increased mortality. However, the genetic and phenotypic profile of snLVEF remains …

Objectives: This study sought to determine the impact of left ventricular diastolic dysfunction
(LVDD) on clinical outcomes in patients undergoing transcatheter aortic valve replacement …

Aortic stenosis (AS) causes left ventricular remodeling (hypertrophy, remodeling, fibrosis)
and other cardiac changes (left atrial dilatation, pulmonary artery and right ventricular …

In patients with severe aortic stenosis (AS), pulmonary hypertension (PH) typically is
indicative of a decompensated disease state with exhausted compensatory mechanisms of …

Objectives The aim of this study was to investigate the relationship between extracellular
volume fraction (ECV), a noninvasive parameter that quantifies the degree of diffuse …

Importance Aortic stenosis (AS) is a major public health challenge with a growing
therapeutic landscape, but current biomarkers do not inform personalized screening and …