Quercetin pretreatment increases the bioavailability of pioglitazone in rats: involvement of CYP3A inhibition

SN Umathe, PV Dixit, KU Bansod, MM Wanjari - Biochemical …, 2008 - Elsevier
Herbal antidiabetic preparations are often used as an add-on therapy in diabetes and such
herbal preparations often contains quercetin that can inhibit cytochrome P450 (CYP) 3A4 …

Laser-scribing fabrication of a disposable electrochemical device for forensic detection of crime facilitating drugs in beverage samples

MV Paschoarelli, MS Kavai, LF de Lima, WR de Araujo - Talanta, 2023 - Elsevier
A portable and disposable laser-scribed graphene (LSG) device was fabricated on
polyetherimide (PEI) substrate for electrochemical detection of benzodiazepines (BZ) drugs …

A novel, palatable paediatric oral formulation of midazolam: pharmacokinetics, tolerability, efficacy and safety

S Salman, EKY Tang, LC Cheung, MN Nguyen… - …, 2018 - Wiley Online Library
Midazolam is one of many bitter drugs where provision of a suitable oral paediatric
formulation, particularly in the pre‐anaesthetic setting, remains a challenge. To overcome …

Preparation, optimization, and evaluation of midazolam nanosuspension: enhanced bioavailability for buccal administration

A Soroushnia, F Ganji, E Vasheghani-Farahani… - Progress in …, 2021 - Springer
Midazolam is considered as one of the best first-line drugs in managing status epilepticus in
children who require emergency drug treatment. Due to poor water solubility, oral …

Effects of gut microbiota on in vivo metabolism and tissue accumulation of cytochrome P450 3A metabolized drug: midazolam

M Togao, K Kawakami, J Otsuka… - … & Drug Disposition, 2020 - Wiley Online Library
The link between drug‐metabolizing enzymes and gut microbiota is well established. In
particular, hepatic cytochrome P450 (CYP) 3A activities are presumed to be affected by gut …

Determination of rivaroxaban in human plasma by solid-phase extraction–high performance liquid chromatography

M Çelebier, T Reçber, E Koçak… - Journal of …, 2016 - academic.oup.com
In this study, a solid-phase extraction (SPE)–high performance liquid chromatography
(HPLC)–ultra violet (UV) method was developed for the determination of rivaroxaban (RIV) …

Optimization of modified dispersive liquid–liquid microextraction coupled with high‐performance liquid chromatography for the simultaneous preconcentration and …

N Goudarzi, S Farsimadan… - Journal of separation …, 2015 - Wiley Online Library
A simple, sensitive, and rapid microextraction method, namely, ultrasound‐assisted
surfactant‐enhanced emulsification microextraction based on the solidification of floating …

Inhibitory effects of baicalin on the expression and activity of CYP3A induce the pharmacokinetic changes of midazolam in rats

X Tian, ZY Cheng, H Jin, J Gao… - … and Alternative Medicine, 2013 - Wiley Online Library
Baicalin, a flavonoid compound isolated from Scutellaria baicalensis, has been shown to
possess antiinflammatory, antiviral, antitumour, and immune regulatory properties. The …

Benzodiazepines: sample preparation and HPLC methods for their determination in biological samples

VF Samanidou, MN Uddin, IN Papadoyannis - Bioanalysis, 2009 - Taylor & Francis
Benzodiazepines (BDZs) belong to a group of substances known for their sedative,
antidepressive, muscle relaxant, tranquilizer, hypnotic and anticonvulsant properties. Their …

Simultaneous HPLC–UV determination of ketamine, xylazine, and midazolam in canine plasma

P Li, H Han, X Zhai, W He, L Sun… - Journal of …, 2012 - academic.oup.com
An isocratic reversed-phase high-performance liquid chromatography method with UV
detection is developed and validated for the simultaneous determination of ketamine …