The life cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) consists of two phases,
latent and lytic. The virus establishes latency as a strategy for avoiding host immune …

The dynamic spatial organization of genomes across time, referred to as the four-
dimensional nucleome (4DN), is a key component of gene regulation and biological fate …

Epstein-Barr virus (EBV) is associated with multiple human malignancies. To evade immune
detection, EBV switches between latent and lytic programs. How viral latency is maintained …

Kaposi's sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus with the
capacity to establish life-long latent infection. During latent infection, the viral genome …

Kaposi's sarcoma-associated herpesvirus (KSHV) primarily persists as a latent episome in
infected cells. During latent infection, only a limited number of viral genes are expressed that …

Epstein–Barr virus (EBV) establishes lifelong asymptomatic infection by replication of its
chromatinized episomes with the host genome. EBV exhibits different latency-associated …

The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated
basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted …

Eukaryotic genomes are structurally organized via the formation of multiple loops that create
gene expression regulatory units called topologically associating domains (TADs). Here we …

During a long history of coevolution, herpesviruses have reached a fine-tuned balance with
their hosts, allowing them to successfully persist and spread to new hosts without causing …

Host cell differentiation-dependent regulation of human papillomavirus (HPV) gene
expression is required for productive infection. The host cell CCCTC-binding factor (CTCF) …