The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …

Abstract Sugars Will Eventually be Exported Transporters (SWEETs) have important roles in
numerous physiological mechanisms where sugar efflux is critical, including phloem …

Highlights•SWEETs are small transporters for sugars undergoing multiple conformational
states during transport cycle.•SWEET9 mediates nectar secretion.•A SWEET–SUT pair …

The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …

The SWEET (sugars will eventually be exported transporter) family was identified as a new
class of sugar transporters that function as bidirectional uniporters/facilitators and facilitate …

Soluble sugars serve five main purposes in multicellular organisms: as sources of carbon
skeletons, osmolytes, signals, and transient energy storage and as transport molecules …

Glucose is the primary fuel to life on earth. Cellular uptake of glucose is a fundamental
process for metabolism, growth, and homeostasis. Three families of secondary glucose …

Biotrophic microbes feeding on plants must obtain carbon from their hosts without killing the
cells. The symbiotic Arbuscular mycorrhizal (AM) fungi colonizing plant roots do so by …

Key message Present review describes the structure, evolution, transport mechanism and
physiological functions of SWEETs. Their application using TALENs and CRISPR/CAS9 …

Eukaryotes rely on efficient distribution of energy and carbon skeletons between organs in
the form of sugars. Glucose in animals and sucrose in plants serve as the dominant …