D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role

A D'Aniello - Brain research reviews, 2007 - Elsevier
d-Aspartic acid (d-Asp), an endogenous amino acid present in vertebrates and
invertebrates, plays an important role in the neuroendocrine system, as well as in the …

Novel neurotransmitters and their neuropsychiatric relevance

SH Snyder, CD Ferris - American Journal of Psychiatry, 2000 - Am Psychiatric Assoc
OBJECTIVE: The purpose of this review is to integrate insights regarding novel
neurotransmitters or neuromodulators of neuropsychiatric significance. METHOD: Evolving …

D-Amino acids in mammals and their diagnostic value

K Hamase, A Morikawa, K Zaitsu - Journal of chromatography B, 2002 - Elsevier
Substantial amounts of d-amino acids are present in mammalian tissues; their function,
origin and relationship between pathophysiological processes have been of great interest …

D-amino acids in the central nervous system in health and disease

SA Fuchs, R Berger, LWJ Klomp… - Molecular genetics and …, 2005 - Elsevier
Recent evidence has shown that d-amino acids are present in animals and humans in high
concentrations and fulfill specific biological functions. In the central nervous system, two d …

d-Amino Acid Levels in Perfused Mouse Brain Tissue and Blood: A Comparative Study

CA Weatherly, S Du, C Parpia, PT Santos… - ACS chemical …, 2017 - ACS Publications
The l-enantiomer is the predominant type of amino acid in all living systems. However, d-
amino acids, once thought to be “unnatural”, have been found to be indigenous even in …

[HTML][HTML] D-Aspartate stimulation of testosterone synthesis in rat Leydig cells

Y Nagata, H Homma, JA Lee, K Imai - FEBS letters, 1999 - Elsevier
d-Aspartate increases human chorionic gonadotropin-induced testosterone production in
purified rat Leydig cells. l-Aspartate, d-, l-glutamate or d-, l-asparagine could not substitute …

d-Aspartate acts as a signaling molecule in nervous and neuroendocrine systems

N Ota, T Shi, JV Sweedler - Amino acids, 2012 - Springer
Abstract d-Aspartate (d-Asp) is an endogenous amino acid in the central nervous and
reproductive systems of vertebrates and invertebrates. High concentrations of d-Asp are …

D‐Aspartic acid is a novel endogenous neurotransmitter

S D'Aniello, I Somorjai, J Garcia‐Fernàndez… - The FASEB …, 2011 - Wiley Online Library
D‐Aspartic acid (D‐Asp) is present in invertebrate and vertebrate neuroendocrine tissues'
where it carries out important physiological functions and is implicated in nervous system …

The role of D-amino acids in Alzheimer's disease

L Piubelli, G Murtas, V Rabattoni… - Journal of Alzheimer's …, 2021 - content.iospress.com
Abstract Alzheimer's disease (AD), the main cause of dementia worldwide, is characterized
by a complex and multifactorial etiology. In large part, excitatory neurotransmission in the …

Neurotransmitter imbalance in the brain and Alzheimer's disease pathology

SG Snowden, AA Ebshiana, A Hye… - Journal of …, 2019 - content.iospress.com
Background: Cholinesterase inhibitors represent three of the four treatments for Alzheimer's
disease (AD), and target the pathological reduction of acetylcholine levels. Here we aimed …