Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Cultured meat is introduced as a valuable traditional meat equivalent. However, before
marketable end products are available, several hurdles need to be overcome. Among …

Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

Skeletal muscle fibers express distinct gene programs during development and maturation,
but the underlying gene regulatory networks that confer stage-specific myofiber properties …

The generation of functional skeletal muscle tissues from human pluripotent stem cells
(hPSCs) has not been reported. Here, we derive induced myogenic progenitor cells (iMPCs) …

The developmental trajectory of human skeletal myogenesis and the transition between
progenitor and stem cell states are unclear. We used single-cell RNA sequencing to profile …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Thyroid hormones (TH) are crucial for development, growth, differentiation, metabolism and
thermogenesis. Skeletal muscle (SM) contractile function, myogenesis and bioenergetic …

Human pluripotent stem cells (hPSCs) can be directed to differentiate into skeletal muscle
progenitor cells (SMPCs). However, the myogenicity of hPSC-SMPCs relative to human fetal …

Skeletal muscle regeneration involves coordinated interactions between different cell types.
Injection of platelet-rich plasma is circumstantially considered an aid to muscle repair but …