Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4‐hydroxy‐2‐nonenal
Lipid peroxidation can be described generally as a process under which oxidants such as
free radicals attack lipids containing carbon‐carbon double bond (s), especially …
free radicals attack lipids containing carbon‐carbon double bond (s), especially …
Oxidative stress in neurodegenerative diseases
E Niedzielska, I Smaga, M Gawlik, A Moniczewski… - Molecular …, 2016 - Springer
The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral
sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being …
sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD), are far from being …
Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease
The blood–brain barrier (BBB) is a tightly regulated interface in the Central Nervous System
(CNS) that regulates the exchange of molecules in and out from the brain thus maintaining …
(CNS) that regulates the exchange of molecules in and out from the brain thus maintaining …
Pharmacological modulation of Nrf2/HO-1 signaling pathway as a therapeutic target of Parkinson's disease
Y Wang, L Gao, J Chen, Q Li, L Huo, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD) is a complex neurodegenerative disorder featuring both motor and
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …
[HTML][HTML] Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease
S Giordano, V Darley-Usmar, J Zhang - Redox biology, 2014 - Elsevier
Oxidative stress including DNA damage, increased lipid and protein oxidation, are important
features of aging and neurodegeneration suggesting that endogenous antioxidant protective …
features of aging and neurodegeneration suggesting that endogenous antioxidant protective …
Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease
Abstract Complex I (NADH dehydrogenase, NDU) and complex IV (cytochrome-c-oxidase,
COX) of the mitochondrial electron transport chain have been implicated in the …
COX) of the mitochondrial electron transport chain have been implicated in the …
SOD2 in mitochondrial dysfunction and neurodegeneration
JM Flynn, S Melov - Free Radical Biology and Medicine, 2013 - Elsevier
The brain is a highly metabolically active tissue that critically relies on oxidative
phosphorylation as a means for maintaining energy. One result of this process is the …
phosphorylation as a means for maintaining energy. One result of this process is the …
Oxidative damage to macromolecules in human Parkinson disease and the rotenone model
LH Sanders, JT Greenamyre - Free Radical Biology and Medicine, 2013 - Elsevier
Parkinson disease (PD), the most common neurodegenerative movement disorder, is
associated with selective degeneration of nigrostriatal dopamine neurons. Although the …
associated with selective degeneration of nigrostriatal dopamine neurons. Although the …
Neuroinflammation and oxidative stress: co-conspirators in the pathology of Parkinson's disease
Parkinson's disease (PD) is a complex disease, with genetics and environment contributing
to the disease onset. Recent studies of causative PD genes have confirmed the involvement …
to the disease onset. Recent studies of causative PD genes have confirmed the involvement …
Metals and Parkinson's disease: mechanisms and biochemical processes
G Bjorklund, V Stejskal, MA Urbina… - Current Medicinal …, 2018 - ingentaconnect.com
Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease
(PD), while the remaining cases are of unknown etiology. It is believed that environmental …
(PD), while the remaining cases are of unknown etiology. It is believed that environmental …