The spinal dorsal horn receives input from primary afferent axons, which terminate in a
modality-specific fashion in different laminae. The incoming somatosensory information is …

The prion protein, PrPC, is a small, cell-surface glycoprotein notable primarily for its critical
role in pathogenesis of the neurodegenerative disorders known as prion diseases. A …

The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron
populations that are critical to process sensory information. Neurons in these areas are …

Pain is a percept of critical importance to our daily survival. In most cases, it serves both an
adaptive function by helping us respond appropriately in a potentially hostile environment …

Allodynia is a state in which pain is elicited by innocuous stimuli. Capsaicin applied to the
skin results in an allodynia that extends to a broad region beyond the application site. This …

Around a quarter of neurons in laminae I–II of the dorsal horn are inhibitory interneurons.
These play an important role in modulating somatosensory information, including that …

2. Methods Experiments were approved by the Ethical Review Process Applications Panel
of the University of Glasgow and were performed in accordance with the UK Animals …

Background Excitatory interneurons account for the majority of neurons in laminae I–III, but
their functions are poorly understood. Several neurochemical markers are largely restricted …

Nociceptive information is relayed through the spinal cord dorsal horn, a critical area in
sensory processing. The neuronal circuits in this region that underpin sensory perception …

Grpr expression defines a population of superficial dorsal h... : PAIN Grpr expression defines a
population of superficial dorsal horn vertical cells that have a role in both itch and pain : PAIN …