A new immunometabolic perspective of intervertebral disc degeneration

V Francisco, J Pino, MÁ González-Gay… - Nature Reviews …, 2022 - nature.com
Intervertebral disc (IVD) degeneration is a common finding on spine imaging that increases
in prevalence with age. IVD degeneration is a frequent cause of low back pain, which is a …

Molecular relationships among obesity, inflammation and intervertebral disc degeneration: are adipokines the common link?

C Ruiz-Fernández, V Francisco, J Pino, A Mera… - International journal of …, 2019 - mdpi.com
Intervertebral disc degeneration (IVDD) is a chronic, expensive, and high-incidence
musculoskeletal disorder largely responsible for back/neck and radicular-related pain. It is …

Food-seeking behavior is triggered by skin ultraviolet exposure in males

S Parikh, R Parikh, K Michael, L Bikovski… - Nature …, 2022 - nature.com
Sexual dimorphisms are responsible for profound metabolic differences in health and
behavior. Whether males and females react differently to environmental cues, such as solar …

Physiological effect of ghrelin on body systems

Y Akalu, MD Molla, G Dessie… - International journal of …, 2020 - Wiley Online Library
Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of
physiological effects. In this review, we found/confirmed that ghrelin has effect on all body …

The role of obesity and diabetes in dementia

A Selman, S Burns, AP Reddy, J Culberson… - International journal of …, 2022 - mdpi.com
Chronic conditions such as obesity, diabetes, and dementia are increasing in the United
States (US) population. Knowledge of these chronic conditions, preventative measures, and …

[HTML][HTML] The role of intestinal macrophages in gastrointestinal homeostasis: heterogeneity and implications in disease

JLK Yip, GK Balasuriya, SJ Spencer… - Cellular and molecular …, 2021 - Elsevier
Intestinal macrophages play a key role in the gut immune system and the regulation of
gastrointestinal physiology, including gut motility and secretion. Their ability to keep the gut …

Leptin in the regulation of the immunometabolism of adipose tissue-macrophages

L Monteiro, JAS Pereira, L Palhinha… - Journal of leukocyte …, 2019 - academic.oup.com
Obesity is a pandemic disease affecting around 15% of the global population. Obesity is a
major risk factor for other conditions, such as type 2 diabetes and cardiovascular diseases …

[HTML][HTML] Gut peptides and the microbiome: focus on ghrelin

NK Leeuwendaal, JF Cryan… - Current Opinion in …, 2021 - journals.lww.com
The gut microbiota may directly or indirectly influence secretion of the orexigenic hormone,
ghrelin, similar to the modulation of satiety inducing GI hormones. Although data …

Effect of gut microbiome on serotonin metabolism: a personalized treatment approach

K Potter, EJ Gayle, S Deb - Naunyn-Schmiedeberg's archives of …, 2024 - Springer
Several factors including diet, exercise, and medications influence the makeup of the
resilient but adaptable gut microbiome. Bacteria in the gut have a significant role in the …

The role of ghrelin and leptin in feeding behavior: Genetic and molecular evidence

ASE García, AGM Moreno, ZR Castillo - Endocrinología, Diabetes y …, 2021 - Elsevier
Feeding behavior is integrated within a wide variety of eating behaviors, which depend on
psychosocial, biological and environmental factors. These types of behavior can cause …