Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

During the past decades, synthetic organic chemistry discovered that directing group
assisted C–H activation is a key tool for the expedient and siteselective construction of C–C …

Cyclic organic molecules are common among natural products and pharmaceuticals,. In fact,
the overwhelming majority of small-molecule pharmaceuticals contain at least one ring …

Transition metal catalyzed C (sp3)–H functionalization is a rapidly growing field. Despite
severe challenges, distal C–H functionalizations of aliphatic molecules by overriding …

We highlight the reported developments of the palladium-catalyzed C–H activation and
functionalization of the inactive/unreactive prochiral C (sp3)–H bonds of aliphatic and …

C–H bond activation/functionalization has undergone a rapid development in the last few
decades, presenting great opportunities for application in biochemistry, material science …

Alkynylation reactions are one of the most sought‐after synthetic methodologies due to the
versatility of C− C triple bond diversifications. Sonogashira coupling was widely used for the …

Alkynes are among the most fundamentally important organic compounds and are widely
used in synthetic chemistry, biochemistry, and materials science. Thus, the development of …

This paper describes Pd (II)‐catalyzed picolinamide‐directed intermolecular arylation and
benzylation of remote δ− C (sp2)− H bond (C (2) position) of the aryl ring in tyrosine …

We report the Pd (II)‐catalyzed bidentate directing group 8‐aminoquinoline‐aided sp3 γ‐C−
H alkylation of 3‐methyl‐thiophene/furan‐2‐carboxylic acid and 3‐methyl‐benzothiophene …