ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …

Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

Abstract Purpose of Review Early-onset Alzheimer's disease (EOAD), defined as
Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the …

Experimental models of Alzheimer's disease (AD) are critical to gaining a better
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …

Early-onset Alzheimer's disease (EOAD) is a rare but particularly devastating form of AD.
Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same …

Accumulation of toxic protein aggregates—amyloid-β (Aβ) plaques and
hyperphosphorylated tau tangles—is the pathological hallmark of Alzheimer disease (AD) …

Multifactorial diseases are characterized by inter-individual variation in etiology, age of
onset, and penetrance. These diseases tend to be relatively common and arise from the …

There is mounting evidence that only a small fraction of early-onset Alzheimer disease
cases (onset< 65 years) are explained by known mutations. Even multiplex families with …

As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …