Microfluidic single-cell manipulation and analysis: Methods and applications

T Luo, L Fan, R Zhu, D Sun - Micromachines, 2019 - mdpi.com
In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a
genetically identical group are the same. This heterogeneity at the single-cell level has been …

Advances in technical assessment of spiral inertial microfluidic devices toward bioparticle separation and profiling: A critical review

M Bagi, F Amjad, SM Ghoreishian… - BioChip Journal, 2024 - Springer
Separation of micro-and nano-sized bioparticles is essential for efficient diagnostics,
chemical and biological analyses, drug development, food and chemical processing, and …

Stem cells applications in regenerative medicine and disease therapeutics

RS Mahla - International journal of cell biology, 2016 - Wiley Online Library
Regenerative medicine, the most recent and emerging branch of medical science, deals
with functional restoration of tissues or organs for the patient suffering from severe injuries or …

An updated review on particle separation in passive microfluidic devices

M Bayareh - Chemical Engineering and Processing-Process …, 2020 - Elsevier
Particle separation has been extensively studied in recent years in a wide range of sciences,
especially in the field of medicine and biotechnology. On the other hand, the topic has been …

Microfluidics for neuronal cell and circuit engineering

R Habibey, JE Rojo Arias, J Striebel… - Chemical …, 2022 - ACS Publications
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

An introduction to the analysis of single-cell RNA-sequencing data

AA AlJanahi, M Danielsen, CE Dunbar - Molecular Therapy Methods & …, 2018 - cell.com
The recent development of single-cell RNA sequencing has deepened our understanding of
the cell as a functional unit, providing new insights based on gene expression profiles of …

High-throughput isolation of circulating tumor cells using cascaded inertial focusing microfluidic channel

A Abdulla, W Liu, A Gholamipour-Shirazi… - Analytical …, 2018 - ACS Publications
Circulating tumor cells (CTCs) are rare cells that detach from a primary or metastasis tumor
and flow into the bloodstream. Intact and viable tumor cells are needed for genetic …

3D printing in biotechnology—An insight into miniaturized and microfluidic systems for applications from cell culture to bioanalytics

C Heuer, JA Preuß, T Habib, A Enders… - Engineering in life …, 2022 - Wiley Online Library
Since its invention in the 1980s, 3D printing has evolved into a versatile technique for the
additive manufacturing of diverse objects and tools, using various materials. The relative …

[HTML][HTML] Effects of obstacles on inertial focusing and separation in sinusoidal channels: An experimental and numerical study

H Cha, HA Amiri, S Moshafi, A Karimi, A Nikkhah… - Chemical Engineering …, 2023 - Elsevier
Inertial microfluidics manipulates and separates microparticles based on the finite inertia of
the fluid at high flow speed. In inertial microfluidics, modifying the geometry by embedding …

Passive microfluidic devices for cell separation

T Zhang, D Di Carlo, CT Lim, T Zhou, G Tian… - Biotechnology …, 2024 - Elsevier
The separation of specific cell populations is instrumental in gaining insights into cellular
processes, elucidating disease mechanisms, and advancing applications in tissue …