Emerging roles of innate and adaptive immunity in Alzheimer's disease

X Chen, DM Holtzman - Immunity, 2022 - cell.com
Alzheimer's disease (AD) is the most common neurodegenerative disease, with
characteristic extracellular amyloid-β (Aβ) deposition and intracellular accumulation of …

Biological aging processes underlying cognitive decline and neurodegenerative disease

MM Gonzales, VR Garbarino, E Pollet… - The Journal of …, 2022 - Am Soc Clin Investig
Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Peripheral and central immune system crosstalk in Alzheimer disease—a research prospectus

BM Bettcher, MG Tansey, G Dorothée… - Nature Reviews …, 2021 - nature.com
Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a
considerable body of evidence indicates pathological alterations in central and peripheral …

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease

RY Pan, L He, J Zhang, X Liu, Y Liao, J Gao, Y Liao… - Cell metabolism, 2022 - cell.com
The pro-inflammatory activation of microglia is a hallmark of Alzheimer's disease (AD), and
this process involves a switch from oxidative phosphorylation (OXPHOS) toward glycolysis …

Long COVID, a comprehensive systematic scoping review

H Akbarialiabad, MH Taghrir, A Abdollahi… - Infection, 2021 - Springer
Purpose To find out what is known from literature about Long COVID until January 30, 2021.
Methods We undertook a four-step search with no language restriction. A preliminary search …

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

MT Heneka, D Golenbock, E Latz, D Morgan… - Alzheimer's research & …, 2020 - Springer
Increasing evidence suggests that infection with Sars-CoV-2 causes neurological deficits in
a substantial proportion of affected patients. While these symptoms arise acutely during the …

The impact of systemic inflammation on Alzheimer's disease pathology

J Xie, L Van Hoecke, RE Vandenbroucke - Frontiers in immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of …

Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling

J Xie, L Cools, G Van Imschoot… - Journal of …, 2023 - Wiley Online Library
The gut microbiota represents a diverse and dynamic population of microorganisms that can
influence the health of the host. Increasing evidence supports the role of the gut microbiota …

Inflammasomes as therapeutic targets in human diseases

Y Li, H Huang, B Liu, Y Zhang, X Pan, XY Yu… - Signal transduction and …, 2021 - nature.com
Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …

Neuroprotective effect of SGLT2 inhibitors

A Pawlos, M Broncel, E Woźniak, P Gorzelak-Pabiś - Molecules, 2021 - mdpi.com
Patients with diabetes are at higher risk of cardiovascular diseases and cognitive
impairment. SGLT2 inhibitors (Empagliflozin, Canagliflozin, Dapagliflozin, Ertugliflozin …