Baculovirus: an insect-derived vector for diverse gene transfer applications

KJ Airenne, YC Hu, TA Kost, RH Smith, RM Kotin… - Molecular Therapy, 2013 - cell.com
Insect-derived baculoviruses have emerged as versatile and safe workhorses of
biotechnology. Baculovirus expression vectors (BEVs) have been applied widely for crop …

Baculovirus as a gene delivery vector: recent understandings of molecular alterations in transduced cells and latest applications

CY Chen, CY Lin, GY Chen, YC Hu - Biotechnology advances, 2011 - Elsevier
Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a
broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity …

Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

S Hindriksen, AJ Bramer, MA Truong, MJM Vromans… - PloS one, 2017 - journals.plos.org
The CRISPR/Cas9 system is a highly effective tool for genome editing. Key to robust
genome editing is the efficient delivery of the CRISPR/Cas9 machinery. Viral delivery …

Production and purification of lentiviral vectors generated in 293T suspension cells with baculoviral vectors

HP Lesch, A Laitinen, C Peixoto, T Vicente… - Gene therapy, 2011 - nature.com
Lentivirus can be engineered to be a highly potent vector for gene therapy applications.
However, generation of clinical grade vectors in enough quantities for therapeutic use is still …

Human enterovirus group B viruses rely on vimentin dynamics for efficient processing of viral nonstructural proteins

P Turkki, M Laajala, M Flodström-Tullberg… - Journal of …, 2020 - Am Soc Microbiol
We report that several viruses from the human enterovirus group B cause massive vimentin
rearrangements during lytic infection. Comprehensive studies suggested that viral protein …

Update on baculovirus as an expression and/or delivery vehicle for vaccine antigens

SY Lin, YC Chung, YC Hu - Expert review of vaccines, 2014 - Taylor & Francis
After three decades of development, the baculovirus/insect cell expression system is now
recognized as a powerful platform for recombinant protein production. With a number of …

[HTML][HTML] Baculovirus-mediated gene delivery and RNAi applications

KE Makkonen, K Airenne, S Ylä-Herttulala - Viruses, 2015 - mdpi.com
Baculoviruses are widely encountered in nature and a great deal of data is available about
their safety and biology. Recently, these versatile, insect-specific viruses have demonstrated …

Baculovirus display: a novel tool for vaccination

ML Pidre, ML Ferrelli, S Haase… - Current Issues in …, 2013 - books.google.com
Baculoviruses are enveloped viruses that infect insect larvae mainly from the order Lepidop‐-
tera. Their genomes are circular double-stranded DNA molecules of about 80 to 180 kbp …

Efficient gene delivery into fish cells by an improved recombinant baculovirus

F Huang, S Cao, X Cui, C Xiong, M Wang, Y Lu… - Journal of virological …, 2011 - Elsevier
Studies on transduction of mammalian cells have shown that baculovirus can be used as an
effective vector for gene delivery. However, previous studies have found the gene delivery …

Quality control and analytical methods for baculovirus-based products

A Roldão, T Vicente, C Peixoto, MJT Carrondo… - Journal of invertebrate …, 2011 - Elsevier
Recombinant baculoviruses (rBac) are used for many different applications, ranging from bio-
insecticides to the production of heterologous proteins, high-throughput screening of gene …