Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …

Osteoporosis and fracture risk are common complex diseases, caused by an interaction of
numerous disease susceptibility genes and environmental factors. With the advances in …

Osteoporosis predisposes patients to spinal fragility fractures. Imaging plays a key role in the
diagnosis and prognostication of these osteoporotic vertebral fractures (OVF). However, the …

Osteoporosis screening, diagnosis, and treatment have gained much attention in the health
care community over the past 2 decades. During this time, creation of multispecialty …

Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000
associations; however, their impact has been limited by the difficulties of causal gene …

The gut microbiome affects the inflammatory environment through effects on T-cells, which
influence the production of immune mediators and inflammatory cytokines that stimulate …

This study sought to redefine the concept of fracture risk that includes refracture and
mortality, and to transform the risk into" skeletal age". We analysed data obtained from 3521 …

Context It is important to identify patients at highest risk of fractures. Objective To compare
the separate and combined performances of bone-related genetic risk scores (GRSs) for …

This chapter describes the burden placed on individuals, healthcare systems and societies
globally by osteoporotic fractures. Osteoporosis constitutes a major public health problem …

The 2019 International Skeletal Dysplasia Society nosology update lists 441 genes for
which mutations result in rare human skeletal disorders. These genes code for enzymes …