Patients with cancer have an increased risk of thromboembolism, which is the second
leading cause of death in these patients. Several mechanisms of the prothrombotic state in …

Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

Increasing evidence suggests that platelets play a predominant role in colon and breast
cancer metastasis, but the underlying molecular mechanisms remain elusive. Glycoprotein …

Abstract The glycoprotein VI (GPVI)-Fc receptor γ (FcRγ) chain is the major platelet signaling
receptor for collagen. Paradoxically, in a FeCl3 injury model, occlusion, but not initiation of …

Deep vein thrombosis (DVT) with its major complication, pulmonary embolism, is a global
health problem. Mechanisms of DVT remain incompletely understood. Platelets play a role …

Circulating platelets roll along exposed collagen at vessel injury sites and respond with
filipodia protrusion, shape change, and surface area expansion to facilitate platelet …

Platelets play a central role in primary hemostasis by forming aggregates that plug holes in
injured vessels. Half a century ago, detailed studies of the microvasculature by electron …

Kinase activation and phosphorylation cascades are key to initiate immune cell activation in
response to recognition of antigen and sensing of microbial danger. However, for balanced …

It has previously been shown in several animal experiments that platelet GPVI (glycoprotein
VI) contributes to thrombosis, particularly in ischemic stroke. Moreover, GPVI levels are …

Platelets play a critical role in vascular inflammation through the podoplanin and
collagen/fibrin receptors, C-type-lectin-like-2 (CLEC-2) and glycoprotein VI (GPVI) …