Advancing precision medicine for acute respiratory distress syndrome

JR Beitler, BT Thompson, RM Baron… - The Lancet …, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome.
Understanding of the complex pathways involved in lung injury pathogenesis, resolution …

Phenotypes and personalized medicine in the acute respiratory distress syndrome

MA Matthay, YM Arabi, ER Siegel, LB Ware… - Intensive care …, 2020 - Springer
Although the acute respiratory distress syndrome (ARDS) is well defined by the
development of acute hypoxemia, bilateral infiltrates and non-cardiogenic pulmonary …

Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome

KD Wick, MA Matthay, LB Ware - The Lancet Respiratory Medicine, 2022 - thelancet.com
The diagnosis of acute respiratory distress syndrome (ARDS) traditionally requires
calculation of the ratio of partial pressure of arterial oxygen to fraction of inspired oxygen …

[HTML][HTML] Acute lung injury–from pathophysiology to treatment

D Mokra - Physiological research, 2020 - ncbi.nlm.nih.gov
Acute lung injury is characterized by acute respiratory insufficiency with tachypnea, cyanosis
refractory to oxygen, decreased lung compliance, and diffuse alveolar infiltrates on chest X …

Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Biomarkers for acute respiratory distress syndrome and prospects for personalised medicine

S Spadaro, M Park, C Turrini, T Tunstall… - Journal of …, 2019 - Springer
Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute
respiratory distress syndrome (ARDS) being the most severe form of ALI and having a …

Clinical trials in acute respiratory distress syndrome: challenges and opportunities

MA Matthay, DF McAuley, LB Ware - The Lancet Respiratory …, 2017 - thelancet.com
This year is the 50th anniversary of the first description of acute respiratory distress
syndrome (ARDS). Since then, much has been learned about the pathogenesis of lung …

[HTML][HTML] Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome

JA Englert, C Bobba, RM Baron - JCI insight, 2019 - ncbi.nlm.nih.gov
Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …

Promises and challenges of personalized medicine to guide ARDS therapy

KD Wick, DF McAuley, JE Levitt, JR Beitler, D Annane… - Critical Care, 2021 - Springer
Identifying new effective treatments for the acute respiratory distress syndrome (ARDS),
including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving …

Inhaled corticosteroids in virus pandemics: a treatment for COVID-19?

DV Nicolau, M Bafadhel - The lancet respiratory medicine, 2020 - thelancet.com
Active discussions are ongoing concerning the efficacy of systemic corticosteroids in COVID-
19, with evidence to support1 and advising against2 their use. Illustratively, a Review3 of …