Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this …

Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual
disability, resulting from the presence of an extra complete or segment of chromosome 21 …

Abstract Types 1 and 2 diabetes affect some 380 million people worldwide. Both ultimately
result from a deficiency of functional pancreatic insulin-producing beta cells. Beta cells …

Restoring functional β-cell mass is an important therapeutic goal for both type 1 and type 2
diabetes. While proliferation of existing β-cells is the primary means of β-cell replacement in …

Down syndrome (DS) is the most frequent genetic cause of intellectual disability and is
strongly associated with Alzheimer's disease (AD). Brain insulin resistance greatly …

Targeting dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) has been
verified to regulate the progression of tau pathology as a promising treatment for Alzheimer's …

Abstract Background and Objectives The Dual-specificity tyrosine-phosphorylation regulated
kinase-1A (DYRK1A) a serine/threonine kinase that has freshly gained recognition as an …

The serine/threonine kinase DYRK1A has been implicated in regulation of a variety of
cellular processes associated with cancer progression, including cell cycle control, DNA …

DYRK1A has been implicated as an important drug target in various therapeutic areas,
including neurological disorders and oncology. DYRK1A has more recently been shown to …

Recently, our group identified that harmine is able to induce β-cell proliferation both in vitro
and in vivo, mediated via the DYRK1A-NFAT pathway. Since, harmine suffers from a lack of …