The immune response to citrullinated antigens is found almost exclusively in patients with
rheumatoid arthritis (RA). It is a dynamic response that expands before the onset of disease …

Rheumatoid arthritis (RA) is caused by prolonged periodic interactions between genetic,
environmental, and immunologic factors. Posttranslational modifications (PTMs) such as …

Objectives To understand the molecular features distinguishing anti-citrullinated protein
antibodies (ACPA) from 'conventional'antibodies in rheumatoid arthritis (RA). Methods …

Rheumatoid arthritis (RA)-associated IgG antibodies such as anti-citrullinated protein
antibodies (ACPAs) have diverse glycosylation variants; however, key sugar chains …

Many autoimmune diseases (AIDs) are characterized by the persistence of autoreactive B
cell responses, which have been directly implicated in disease pathogenesis. How and why …

Recently, we showed the unexpectedly high abundance of N-linked glycans on the Fab-
domain of Anti-Citrullinated Protein Antibodies (ACPA). As N-linked glycans can mediate a …

The presence of autoantibodies is a defining feature of many autoimmune diseases. The
number of unique autoantibody clones is conceivably limited by immune tolerance …

В обзоре рассмотрены новые данные, касающиеся иммунопатологии ревматоидного
артрита (РА), с акцентом на раннюю стадию заболевания. Эволюция РА включает …

Objective Mast cells may play a role in rheumatoid arthritis (RA), but activation of human
mast cells in autoimmune settings has been little studied. Toll-like receptors (TLR) and Fcγ …

Background Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated
and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although …