Recurrent pregnancy loss (RPL) has become an important reproductive health issue
worldwide. RPL affects about 2%–3% of reproductive-aged women, and makes serious …

To ensure successful offspring ploidy, vertebrate oocytes must halt the cell cycle in meiosis II
until sperm entry. Emi2 is essential to keep oocytes arrested until fertilization. However, how …

Dear Editor, Cyclins and cyclin-dependent kinases regulate both mitotic and meiotic cell
cycles [1]. Most cyclins are ubiquitously expressed; however, a few are unique to the …

BACKGROUND The reproductive system plays a crucial role in insect survival, reproduction
and species specificity. Understanding the molecular mechanisms underlying reproductive …

Recurrent miscarriage (RM) is defined by the occurrence of at least two pregnancy losses
prior to 22 weeks of gestation and affects up to 5% of couples trying to conceive. 1–3 RM …

Background Oocyte maturation arrest results in female infertility and the genetic etiology of
this phenotype remains largely unknown. Previous studies have proven that cyclins play a …

Background The precise etiology of approximately 50% of patients with recurrent
spontaneous abortion (RSA) is unclear, known as unexplained recurrent spontaneous …

Cyclins are the main driver of the cell cycle and are indispensable for correct cell division.
Cyclins prevent aneuploidy, which is a hallmark of cancer in the case of mitosis and a risk …

For the formation of new life by the fusion of egg and sperm it is essential that the resulting
organism contains again the same number of chromosomes as the parents9 cells. This is …

Les cellules germinales mâles (spermatozoïdes) et femelles (ovocytes) se divisent par
méiose, une étape-clé de la reproduction sexuée. Cette division spécialisée assure la …